Dextran

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dextran

[′dek ‚stran]
(biochemistry)
Any of the several polysaccharides, (C5H10O5)n , that yield glucose units on hydrolysis.

Dextran

 

(C6H10O5)n, a polysaccharide of bacterial origin, a polymer of glucose. The molecular weight can be as high as 10,000,000. In the linear part of the dextran molecule the glucose residues are joined by bonds between the first and sixth carbon atoms; branching is due to bonds between the first and fourth, first and third, and first and second atoms. Dextran is obtained by growing microorganisms of the genus Leuconostoc in an artificial culture medium. Dextran, in the form of a partially hydrolyzed solution with not less than 90 percent 1.6 linkages and a molecular weight of about 60,000 is used clinically as a blood plasma substitute. The preparation provides for a normal osmotic pressure corresponding to that of blood. Modified dextran, so-called Sephadex, is used in chromatography.

References in periodicals archive ?
Several authors disclosed ties to FAST Biomedical; one author disclosed ties to TdB Consultancy, which collaborates with FAST BioMedical on dextran development.
Generally, dextrans from the genus Weissella are highly linear with few branches.
Figure 6 shows the hydrophilicity of PS microspheres and PS-Dex grafted with various molecular weight of dextrans. The hydrophobic surface of PS microspheres results in very poor water diffusion into the inner pores of the particles, which consequently leads to poor hydrophilicity.
We then examined the potential role of the junctions in regulating the passage of materials between epithelial cells into the animal by testing the permeability of the epithelium with fluorescent dextrans of varying sizes.
Two studies evaluated the influence of Dextran in thermal stability of Bovine Serum Albumin (BSA) (ANTONOV & WOLF, 2005) and [beta]-Lactoglobulin ([beta]-Lg) (VARDHANABHUTI et al., 2009) and concluded that in both cases the polysaccharide was able to reduce the thermal stability of the protein in low pH and in high concentrations of Dextran.
Four main iron preparations are used in the USA: two iron dextrans (LMWID, INFeD; HMWID, Dexferrum), sodium ferric gluconate (Ferrlecit), iron sucrose (Venofer), and ferumoxytol (Feraheme) [23-27].
Dextrans are sugar molecules linked together into long chains that improve the texture and taste of the sourdough and help keep the bread fresh.
To investigate the ability of biological polymers to penetrate the interior volume of the PW-HGMs, we performed experiments using fluorescently-labeled dextrans, proteins, and nucleic acids.
She pointed out that the new dextrans may act as so-called "prebiotics," non-digestible food ingredients that stimulate the growth or activity of bacteria in the digestive system which are beneficial to health.
The available IV iron compounds are iron dextran, iron sucrose, and sodium ferric gluconate.
DES6 is a member of the sulfated dextran family of compounds that attach to the surface of a virus's coat and prevent it from infecting target cells.
The inhibitory effect of dextrans suggests that DE induced lysis results from hydrophilic pore formation in the lipid bilayer of the red blood cell rather than from a detergent-like disruption of lipid packing or from phospholipase activity.