Diabetes Insipidus

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Related to Diabetes Insipidus: nephrogenic diabetes insipidus, diabetes mellitus, SIADH

diabetes insipidus

[‚dī·ə′bēd·ēz in′sip·ə·dəs]
A form of diabetes due to a disfunction of the hypothalamus.

Diabetes Insipidus


an endocrine disease caused by a low content of the hormone vasopressin in the blood. It is characterized by constant intense thirst and excessive excretion of urine. Diabetes insipidus patients excrete 5 to 50 liters a day of transparent urine with a very low specific gravity (1.005-1.001); the urine is odorless and contains no pathological components, including sugar (unlike the urine of diabetes mellitus patients). As a result of dehydration, diabetes insipidus patients suffer from dryness of the skin and mucous membranes, marked emaciation, general weakness, depression, vertigo and headaches, nausea, and sometimes even vomiting. Diabetes insipidus is caused by injury (owing to infection, tumor, or trauma) to the hypothalamus and pituitary, which form a unified functional system that regulates the excretion of salts and water by the kidneys. A hereditary predisposition to the disease is sometimes noted, and the trait is dominant. Treatment consists of hormonal preparations; chemotherapy is prescribed if the disease is of infectious or inflammatory origin.


Atabek, A. A. Nesakharnyi diabet. Moscow, 1951. (Bibliography.)
Ginetsinskii, A. G. Fiziologicheskie mekhanizmy vodno-solevogo ravnovesiia. Moscow-Leningrad, 1963.
Leaf, A. “Diabetes Insipidus.” In Clinical Endocrinology, vol. 1. New York-London, 1960. Page 73. (Bibliography.)


References in periodicals archive ?
In cases where the diabetes insipidus is mild, patients who are able to drink, have unlimited access to fluids, and have a normal thirst mechanism may be able to regulate their own fluid balance (Singer & Sevilla, 2003)).
Hydrocortisone dose and postoperative diabetes insipidus in patients undergoing transsphenoidal pituitary surgery: a prospective randomized controlled study.
Merkezi diabetes insipidus (DI) polidipsi, poliuri, susuz kalma, huzursuzluk, yetersiz beslenme, yetersiz buyume ve hipernatremiye yol acan, antidiuretik hormonun (ADH) yetersizligi sonucu ortaya cikan bir klinik tablodur (1,2).
Thus, both diabetes mellitus and diabetes insipidus relate to a malfunction of two analogous transport systems.
Physical therapy focused on walking, coordination and balance, tn the midst of all this, she was living with diabetes insipidus.
The panhypopituitarism and diabetes insipidus that resulted necessitated pharmacologic therapy.
She had diabetes insipidus, a seizure disorder, and a history of cervical dysplasia.
Lily is just one of two babies currently being treated in Britain for diabetes insipidus - where the kidneys fail to retain water.
Diabetes insipidus is associated with colorless urine, the ingestion of ethyl alcohol, and hypercalcemia, a condition caused by too much calcium in the system because of faulty metabolization.

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