diastereomer

(redirected from Diastereoselectivity)

diastereomer

[¦dī·ə¦ster·ē′ō·mər]
(organic chemistry)
References in periodicals archive ?
In one successful example, the utilizing of chiral amine (1) in 3C-Ugi reaction had induced high diastereoselectivity to the formation of aminoamide derivatives (4R:4S, >95%) (Scheme 1) [14].
More analysis foradduct8exhibited that the reaction was carried out in high diastereoselectivity. Adduct 8 have 4 chiral centers; however, this synthetic protocol affords only one diastereomer.
In conclusion, we report the reaction of dielectrophilic precursor 4,4,4-trifluoro-3,3-dihydroxy-2-methyl-1-(thien-2-yl)-1-butanone with hydroxylamine hydrochloride to regiospecifically produce a diasteroisomeric mixture of 5-trifluoromethyl-5-hydroxy-4-methyl-3-(thien-2-yl)-4,5-dihy droisoxazole, demonstrating a degree of diastereoselectivity through cyclocondensation reactions; we also reacted it with hydrazine hydrochloride to produce aromatic 5-trifluoromethyl-4-methyl-3-(thien-2-yl)-1H-pyrazoles.
Banerjee, "Ionic liquid promoted interrupted Feist-Benary reaction with high diastereoselectivity," Tetrahedron Letters, vol.
Butcher, "Highly efficient one-pot, three-component Mannich reaction catalysed by boric acid and glycerol in water with major 'syn' diastereoselectivity," Tetrahedron Letters, vol.
Tasheva., The origin of diastereoselectivity in the Michael addition reaction: a computational study of the interaction between CH-acidic Schiff base and [alfa], [beta]- unsaturated ketones, Tetrahedron, 66(27-28), 5168-5172 (2010).
Reaction of 3 with lithium tributylstannane occurs with high levels of diastereoselectivity, such that only one isomer of 4 is observed.
These findings support the assumption that the structure of the substrate is the most important factor in the control of reaction diastereoselectivity. We could not observe the inversion of the diastereomeric ratio during the reaction or work-up procedures.
Kulawiec, "Diastereoselectivity in enolate coordination in a new class of chiral ruthenium enolate complexes," Organometallics, vol.
reported that the highly polar phosphine oxide moiety of the chiral Michael catalyst interacts with the nitro group of Michael acceptor via dipole interactions mediated by water to produce high yield and enantio- and diastereoselectivity [14].
The reactions proceed in high yields with near complete diastereoselectivity. The tetrahydro-1,2-oxazine ring is a key structural element of the anti-cancer compound FR900482 7.