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congenital anomaly of the metabolic processes of an organism in which the functions and metabolism of the organism enter a state of prolonged unstable equilibrium that is expressed in unique pathological reactions and illnesses.

The inherited predisposition is actually the result of a unique accumulation through preceding generations of characteristics that occur in the organism both owing to the effect of unfavorable environmental conditions and in association with congenital anomalies of the organism’s internal environment. The mechanism of development of diathesis is closely linked with the autonomic nervous system and internal secretion. When conditions of the external environment grow worse (disruption of diet or schedule, illness of the organism) and with functional impairment of the central or autonomic nervous system, the neural regulatory mechanisms cannot ensure proper functioning by organs and proper metabolism. As a result the organism’s ability to adapt to the environment is reduced, its reactivity changes, and a predisposition to certain diseases arises. With diathesis even physiological stimuli and ordinary living conditions can cause pathological reactions and lead to illness. The predisposition to illnesses can be lessened and sometimes even eliminated.

Diathesis usually manifests itself during childhood. Sometimes constitutional anomalies can only be identified by careful investigation of the functional state of the central and autonomic nervous systems and investigation of morphological, functional, and biochemical changes in a number of systems and in the metabolism of the organism as a whole. There are different forms of diathesis. The most commonly encountered are exudative-catarrhal diathesis, lymphatic-plastic diathesis, and neural-arthritic diathesis. The manifestations of neural-arthritic diathesis change with age; in the nursing stage there is a causeless disposition to impairments of digestion and diet, increased nervous excitability, and other characteristics, while later abnormal emaciation or obesity occurs and there is vomiting during mental excitation, cardiospasm, and so on. There is no clear distinction between different forms of diathesis, and therefore they are sometimes considered variations of one diathesis that manifests itself differently depending on age. The hemorrhagic diatheses constitute a special group.

References in periodicals archive ?
Because the opposition between SM- and GM-diathesis is not reflected in the morphological form of the verb, at first glance it is difficult to pinpoint the primary diathesis. However, if one defines markedness more broadly than what is manifested by morphology only (see e.g.
They had developed hepatic encephalopathy and bleeding diathesis in their final hours.
It has 60 items, which contains nine subscales: gentleness, qi-deficiency, yang-deficiency, yin-deficiency, phlegm-dampness, dampness-heat, blood-stasis, qi-depression, and special diathesis. Score of each subscale is standardized from 0 to 100.
Owren, "Parahaemophilia; haemorrhagic diathesis due to absence of a previously unknown clotting factor," The Lancet, vol.
Normally, lithium is not present in significant amounts in body fluid (less than 0.2 mEq/L), however lithium salts have been used therapeutically for almost 150 years, beginning with its use for the treatment of gout (or uric acid diathesis) in the 1850s.7 Although gout was believed to include symptoms of mania and depression, it wasn't until 1880s that John Aulde and Carl Lange observed that lithium could be used to treat symptoms associated with depression, independent of gout .7 However the use of lithium became problematic and was discarded due to the serious toxicity associated with the widespread use of lithium in tonics, elixirs and as salt substitute.7
It is known that hemorrhagic diathesis together with psychogenic disorders is present in this syndrome, but the cause and frequency of hematological disorders is not known.
Haemophilia A is an X-linked recessive genetic defect, with a frequency of approximately 1 in 8,500 live births, resulting in coagulation factor VIII deficiency and bleeding diathesis. Haemorrhage into large joints and muscles, from the ears and nose, and following surgical challenge is a particular feature.
Renal biopsy was not performed for the bad and severe clinic condition especially bleeding diathesis of this patient.
The presence of edema resulted in an infective diathesis, resulting in seeding of the muscles of the dorsal forearm by MSSA during the transient bacteremia occurring during incision and drainage of the chin abscess.
Another important issue is the difficulty in treatment caused by the coexistence of bleeding diathesis and malignancy.
In addition, the new model identifies three different neurobiological systems that could play a role in diathesis (organic predisposition) to suicidal behaviour.
Also evaluate women for bleeding diathesis, such as von Willebrand's disease, prior to ablation.