Diisopropyl Fluorophosphate

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Diisopropyl Fluorophosphate

 

(iso-C3H7O)2P(O)F, a colorless liquid with a slight odor. Melting point, −82°C; boiling point, 67.5°C (12 mm Hg); density, 1.0682 g/cm3 (20°C); and refractive index nD20, 1.3832. Diisopropyl fluorophosphate is slightly soluble in water (1.5 percent) but is readily soluble in organic solvents. Water hydrolyzes it very slowly (reaction of an autocatalytic nature), but it reacts vigorously with alkalis and aqueous solutions of ammonia and amines. It is prepared by the action of potassium fluoride on diisopropyl chlorophosphate. Diisopropyl fluorophosphate causes convulsions, paralysis, and miosis (contraction of the pupil of the eye). A concentration of approximately 0.08 mg// will produce strong miosis. Diisopropyl fluoro-phosphate is used in the physiological and pharmacological studies of the nervous system and as an inhibitor of numerous enzymes in enzymological research.

REFERENCES

Sartori, M. “Novoe v khimii boevykh otravliaiushchikh veshchestv.” Uspekhi khimii, 1954, vol. 23, issue 1, p. 62.
O’Brien, R. Toksichnye efiry kislot fosfora. Moscow, 1964. (Translated from English.)
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Stossel, "Prevention of degradation of human polymorphonuclear leukocyte proteins by diisopropylfluorophosphate," Blood, vol.
Caption: Figure 1: Cell-penetrating serine protease inhibitor diisopropylfluorophosphate blocks FPR1 cleavage in solid phase assay of FPR1 phosphorylation.
Barstad JAB (1956) The effect of d-turbocurarine on the neuro-muscular blocks caused by diisopropylfluorophosphate and acetylcholine.
Chlorpyrifos, chlorpyrifos-oxon, and diisopropylfluorophosphate inhibit kinesin-dependent microtubule motility.
Chronic impairments in spatial learning and memory in rats previously exposed to chlorpyrifos or diisopropylfluorophosphate. Neurotoxicol Teratol 34(1):1-8, PMID: 22024239, https://doi.org/10.1016/j.ntt.2011.08.015.
This is likely to play an important role in neuroprotection against organophosphates: forskolin, which stimulates adenylyl cyclase directly, preserves neural cells from the adverse effects of diisopropylfluorophosphate, potentially by promotion of differentiation, which up-regulates acetylcholinesterase itself (Curtin et al.
Ahlbom and colleagues exposed neonatal mice to a single oral dose of the organophosphate diisopropylfluorophosphate on either postnatal day 3, 10, or 19.