dioxolane


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dioxolane

[dī′äk·sə‚lān]
(organic chemistry)
C3H6O2 A cyclic acetal that is a liquid; used as a solvent and extractant.
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References in periodicals archive ?
Their topics include the chemical synthesis of acyclic nucleosides, mononucleotide pro-drug synthetic strategies, synthesizing conformally constrained nucleoside analogues, stereoselective methods in synthesizing bioactive oxathiolate and dioxolane nucleosides, and synthetic studies on antifungal peptidyl nucleoside antibiotics.
Chemical synthesis of nucleoside analogues
My last remuneration for a drug study was more than 45 years ago, when I tested a combination of dioxolane and reserpine.
Staying within the boundaries
Dioxolane guanosine 5'-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase.
New drugs
Troxacitabine was discovered by BioChem Pharma and is the first dioxolane nucleoside analogue anticancer agent.
BioChem Pharma begins phase II trials of troxacitabine, a novel anticancer compound
Our new "DOI" dioxolane based (meth)acrylates offer low skin irritation and unique properties.
International Coatings Expo exhibitor booth descriptions
Laval, Canada) has patented a process for stereoselectively producing a dioxolane nucleoside analogue from an anomeric mixture of .
Biochem Pharma obtains United States patent
Dimers of gA can be obtained by introduction of a dioxolane ring between N-formylated termini of two gA molecules.
Chemical stop signs: controlling proton flow with carbonyls
Troxatyl(TM) (troxacitabine) is the first dioxolane nucleoside analog to be investigated as an anticancer agent in clinical trials.
BioChem Pharma Inc. - Troxatyl(TM) Featured At The American Society of Clinical Oncology's 37th Annual Meeting
A second drug in this class is amdoxovir (also called diaminopurine dioxolane or DAPD).
Investigational HIV drugs promising. (More Convenient, Less Toxic)
Seebach discussed the catalytic use of similar complexes derived from tetraaryl dioxolane dimethanols (TADDOLs) and tetraisopropoxy titanium to mediate asymmetric addition of organozinc compounds to compounds such as saturated and unsaturates aldehydes.
Industry: academic mix contributes to forum's success
DAPD is a novel dioxolane purine nucleoside reverse transcriptase inhibitor (NRTI) that is in Phase I/II trials for the treatment of HIV.
Triangle Pharmaceuticals and Abbott Laboratories Report Drug Candidate DAPD Decreases Viral Load in Patients Infected With Resistant Virus When Added to Failing Drug Regimens
DAPD is a novel dioxolane purine nucleoside reverse transcriptase inhibitor (NRTI) that is rapidly converted in humans into its active metabolite, DXG.
Triangle Pharmaceuticals Reports First Human Data From Phase I/II Study Of DAPD in HIV-Infected Patients

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