Recent work revealed that secretion from renal tubule epithelial cells occurs primarily from the distal tubule
for TIMP-2 and the proximal tubule for IGFBP7.
Tubulo-glomerular feedback is a normal intra-renal mechanism whereby increased solute delivery to distal tubule
results in afferent arteriolar vasoconstriction.
In the distal tubule
incomplete concentration of intraluminal fluid (urine) occurs at the cost of K+ loss.
Brief report: Liddle's syndrome revisited – A disorder of sodium reabsorption in the distal tubule
Gitelman's syndrome (GS) is an inherited hypokalemic salt-losing tubulopathy with secondary hyperaldosteronism that affects the thiazide-inhibitable sodium-chloride cotransporter (NCCT) of the distal tubule
, making its presentation similar to that of treatment with thiazide diuretics.
2 A-B) shows Bowman's capsule surrounded renal Glomerulus (G), and separated by a distance of Urinary space (U S), also showing Proximal tubule (PT) and Distal tubule
A large percentage of magnesium is reabsorbed paracellularly in the thick ascending limb, with a smaller transcellular flux in the distal tubule
Specific diuretics Class Drug Comments Thiazide Chlorothiazide Chlorthalidone Thiazide-like in action, not in structure Hydrochlorothiazide Prototypical drug Hydroflumethiazide Indapamide Thiazide-like in action, not in structure Methyclothiazide Metolazone Thiazide-like in action, not in structure Polythiazide Loop Bumetanide Ethacrynic acid Furosemide Torsemide K+-sparing Amioloride Distal tubule
Among specific topics are lysosomal acidification mechanisms, a new look at electrolyte transport in the distal tubule
, autophagy in pulmonary diseases, and interaction between sperm and egg.
The distal tubular acidosis decreases the secretion of H + and is characterized by an inability of the distal tubule
to lower urine pH <5.
In RTA I, the distal tubule
is unable to acidify the urine and results in a urine pH that is above 5.
Disintegration of glomerulus, proximal tubule and necrosed hematopoietic tissues with disorganized glomerular tuft, distal tubule
and pycnotic nuclei were noted at 75 mg/L (Fig.