Disulfiram


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disulfiram

[di′səl·fə‚ram]
(pharmacology)
C10H20N2S4 A drug used to treat alcohol abuse that blocks the metabolism of acetaldehyde, the major metabolite of ethanol, causing a rapid buildup of acetaldehyde and a severe physiological syndrome intended to prevent or modify further immediate drinking behavior. Also known as Antabuse.

Disulfiram

 

(also teturamin, Antabuse), a drug used to treat alcoholism. Disulfiram inhibits the oxidation of alcohol, causing acetic aldehyde to accumulate. As a result, the consumption of alcohol leads to such symptoms as sensation of heat, tightness in the chest, heart palpitations, anxiety, and vomiting. Disulfiram is taken orally in the form of tablets. Treatment is first undertaken in a hospital.

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Patients who are likely to respond well to disulfiram treatment are older; have a longer drinking history; greater social stability, impulsivity, and motivation for recovery; attend Alcoholics Anonymous meetings; and are cognitively intact (Fuller and Gordis 2004; Suh et al.
disulfiram no generic 250 mg/day Trade formulation only.
But disulfiram can also increase the accumulation of other, potentially addictive compounds.
No se encontraron diferencias significativas entre los grupos de tratamiento en lo referente a las siguientes variables: uso de Disulfiram, abandonos y adherencia al tratamiento.
Several ALDH inhibitors have been used to cause massive acetaldehyde accumulation after alcohol consumption, most commonly disulfiram and cyanamide.
A similar process of cognitive and behavioural change has been reported with long-term alcoholism treatment programmes incorporating supervised disulfiram. (44) It supports our previous suggestion that a minimum period of between one and two years of AAA is usually needed for such changes to become well established and automatic.
EVIDENCE SUMMARY Naltrexone (50 mg qd), nalmefene (10-80 mg qd), and acamprosate (dose based on patient weight) are all superior to placebo and other agents such as the SSRIs, disulfiram, and serotonergic agents in reducing relapse rates and the phenomena of craving and in increasing abstinence rates.
Based on drug type, the market has been segmented into bupropion, varenicline, acamprosate, disulfiram, naltrexone, methadone, buprenorphine, nicotine replacement products, and others.
Revising entries for Disulfiram, Thiuram, Thiuram disulfides, and Thiuram monosulfides to combine under a single entry for Thiurams (CAS 97-77-8; 137-26-8) with a maximum use of 14% in latex products
Psychopharmacologic management includes US Food and Drug Administration (FDA)-approved medications such as disulfiram, naltrexone, and acamprosate, and off-label uses of other medications (table 4 (9)).