Patients who are likely to respond well to disulfiram
treatment are older; have a longer drinking history; greater social stability, impulsivity, and motivation for recovery; attend Alcoholics Anonymous meetings; and are cognitively intact (Fuller and Gordis 2004; Suh et al.
no generic 250 mg/day Trade formulation only.
can also increase the accumulation of other, potentially addictive compounds.
Safety issues concerning the use of disulfiram
in treating alcohol dependence.
No se encontraron diferencias significativas entre los grupos de tratamiento en lo referente a las siguientes variables: uso de Disulfiram
, abandonos y adherencia al tratamiento.
Several ALDH inhibitors have been used to cause massive acetaldehyde accumulation after alcohol consumption, most commonly disulfiram
A similar process of cognitive and behavioural change has been reported with long-term alcoholism treatment programmes incorporating supervised disulfiram
. (44) It supports our previous suggestion that a minimum period of between one and two years of AAA is usually needed for such changes to become well established and automatic.
EVIDENCE SUMMARY Naltrexone (50 mg qd), nalmefene (10-80 mg qd), and acamprosate (dose based on patient weight) are all superior to placebo and other agents such as the SSRIs, disulfiram
, and serotonergic agents in reducing relapse rates and the phenomena of craving and in increasing abstinence rates.
is prototypic aversive agent that prevents the breakdown of acetaldehyde, a toxic metabolite of alcohol.
Based on drug type, the market has been segmented into bupropion, varenicline, acamprosate, disulfiram
, naltrexone, methadone, buprenorphine, nicotine replacement products, and others.
Psychopharmacologic management includes US Food and Drug Administration (FDA)-approved medications such as disulfiram
, naltrexone, and acamprosate, and off-label uses of other medications (table 4 (9)).