disulfide

(redirected from Disulphides)
Also found in: Dictionary, Medical.

disulfide

[dī′səl‚fīd]
(chemistry)
A compound that has two sulfur atoms bonded to a radical or element.
One of a group of organosulfur compounds RSSR′ that may be symmetrical (R=R′) or unsymmetrical (R and R′, different).
References in periodicals archive ?
Native thiol, total thiol, disulphide levels and disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol ratios were compared between the patient and control group's sera.
The AA group had a significantly decreased native thiol/total thiol ratio and a significantly increased disulphide level, disulphide/native thiol, and disulphide/total thiol ratios (p<0.01) (Table 2).
No correlation was found between the total thiol level, native thiol level, and native thiol/total thiol ratio and significantly increased disulphide level, disulphide/native thiol, and disulphide/total thiol ratios levels as analyzed by BMI, lesion duration, disease pattern, and recurrence frequency (p>0.05) (Table 3).
Aiming for a difference of approximately 5 [micro]mol/L in disulphide levels between PCOS and non-PCOS patients, we calculated the sample size of each group with an alpha level of 5% and a p error level of 50%.
Dynamic disulphide bridges were reduced to functional thiol groups by sodium borohydride.
Disulphide levels and the ratios of disulphide/native thiols and disulphide/total thiols in follicular fluid were higher in women with PCOS (13.2[+ or -]2.7 [micro]mol/L, 4.5%[+ or -]1.2%, 4.1%[+ or -]1.0%, respectively; p<0.0001) compared with non-PCOS controls (8.5[+ or -]3.2 [micro]mol/L, 2.8%[+ or -]1.2%, 2.5%[+ or -]1.2%, respectively; p<0.0001).
The plotting of increases in intracellular [Ca.sub.2+] concentration ([[[Ca.sub.2+]].sub.i]) via each recombinantly expressed redox-sensitive TRP channels against the [E.sub.1/2] values of reactive disulphides used for stimulation revealed a positive correlation.
Our quantitative analysis of the reactivity of redox-sensitive TRP channels revealed that TRPA1 has the highest sensitivity to disulphides among the TRPs that we tested, predicting that only TRPA1 responds to a relatively inert electrophile, diallyl disulphide, with a redox potential of -2,950 mV.
Thiols can undergo oxidation reaction via oxidants and form disulphide bonds.
The current study was planned to investigate some of the new inflammatory markers such as raftlin and presepsin, andoxidative stress markers, such as thiol and disulphide bonds, in acute appendicitis and to compare these parameters with conventional clinical diagnostic variables WBC and CRP in diagnosing or excluding acute and perforated appendicitis.
The serum disulphide levels of silica-exposed workers were significantly higher than control subjects (23.84[+ or -]5.89 [micro]mol/L and 21.18[+ or -]3.44 [micro]mol/L, respectively p=0.02).
Conclusion: The serum disulphide levels, a biomarker of oxidative stress, are found to be higher in silica-exposed workers.