DNA microarray

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DNA microarray

[¦dē¦en¦ā ′mī·krō·ə‚rā]
(cell and molecular biology)
A microscopic spot containing identical single-stranded polymeric molecules of deoxyribonucleotides (DNAs), usually oligonucleotides or complementary DNAs, attached to a solid support (such as a membrane, a polymer, or glass) used to simultaneously analyze the expression levels of the corresponding genes.
References in periodicals archive ?
Finally, both mixes were pumped to the DNA array portion of the CARD (Supplemental Figure 1, zone 3).
According to him, these structures are about 100 nanometres in diameter, eight times larger and three times more complex than what could be created within a simple crystalline DNA array.
With this technology, cells or tissues are exposed to toxicants, and then gene expression is measured by collecting mRNA, converting mRNA to labeled cDNA, hybridizing it to the DNA array, staining it with an appropriate dye, and visualizing the hybridized genes using a fluorometer (DeRisi et al.
San Diego, CA 8/19/04--Illumina and Applera have settled two lawsuits stemming from a November 1999 joint development agreement to develop, manufacture and market high-throughput DNA array systems (see IBO 11/15/99) based on Illumina's BeadArray technology and the ZipCode chemistries of Applied Biosystems.
DNA Array Deal-Making is Slowing DNA Array Related Deals 2000 2001 2002 * Affymetrix 20 12 5 Agilent Technologies 6 9 2 Incyte 6 8 0 Luminex 7 7 2 Lynx Therapeutics 5 7 0 Genicon Sciences 0 4 0 Genomic Solutions 2 4 3 Nanogen 12 4 6 Qiagen 3 4 2 Subtotal 61 59 20 * Through July Source: Cambridge Healthtech Institute ** Changes in the use of microarrays are reflected in the fewer number of business deals that are now occurring * Resources
By using the Maskless UV Projector to control the patterning of UV light on a glass surface in the reaction chamber, NimbleGen achieves great precision and control over DNA array fabrication and structure.
(Santa Clara, CA; 408-731-5000) says it purchased a license to the Southern DNA array patents owned by Oxford Gene Technology (Oxford, United Kingdom; 44-171-496-3300).
The procedure is as follows: blood samples are shipped to a central laboratory, where DNA is analyzed with the first CE-marked (approved for sale in the European Community) DNA array for in vitro diagnosis in Europe.
If Incyte prevails in these interference proceedings, Affymetrix' ability to enforce intellectual property in the DNA array field would be severely damaged.
In total, the DNA array will allow a diagnosis in ~40% of the clinically diagnosed ADH patients.
San Francisco, CA; 650-246-2300) announced that they have entered into a DNA array internal use license agreement.
Affymetrix plans to strengthen its DNA array market position by introducing arrays of whole genomes of major model organisms, providing customers with Internet access to array results, and offering software products for its arrays.