Caption: Abreva utilizes docosanol
for deep penetration.
(Abreva) is an over-the-counter cream for cold sores.
As topical medications, penciclovir (Denavir[R]) and docosanol
(Abreva[R]) are prescribed for treatment and prevention of orofacial herpes simplex (Vallerand et al., 2017).
Several topical medications (acyclovir, penciclovir, docosanol
) modestly decrease healing time and pain duration--typically by less than a day--and require multiple doses per day (SOR: B, multiple RCTs).
had constructed a novel approach for targeted delivery of the drug using SWCNTs-lipid-drug methodology in which a long chain lipid molecule (nontoxic docosanol
) is covalently linked to the drug molecule .
TOP TIP: new Blistex Cold Sore Cream PS6.99, contains the active ingredient docosanol
. It's the first time this 'magic' ingredient has been available in the UK after having huge success in the US.
Prescription and over-the-counter topical antivirals, such as docosanol
, acyclovir, and penciclovir, speed healing by about half a day.
Meanwhile, currently available prescription and over-the-counter topical antivirals, such as docosanol
, acyclovir, and penciclovir, speed healing by only about half a day.
(Abreva[R]), a behenyl alcohol, became the first over-the-counter (OTC) antiviral drug sold in the U.S.
Acyclovir cream shortens outbreaks by about 0.5 to 0.6 days; penciclovir cream by 0.7 to 1 day, and docosanol
cream, by 18 hours, Dr.
The macromonomers used in this study were derived from dodecanol, octadecanol, and docosanol
. The details of stepwise synthesis are described elsewhere.