drug tolerance


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Related to drug tolerance: drug withdrawal

drug tolerance

[′drəg ‚tä·lə·rəns]
(medicine)
Condition that may follow repeated ingestion of a drug in so that the effect produced by the original dose no longer occurs.
References in periodicals archive ?
Further analysis was done to quantitatively assess the drug tolerance according to average dosage of methotrexate at different visits.
Following are 22 contributions addressing commercial applications of synthetic biology, the genome as the unit of engineering, biofilm biosensors, sociomicrobiology, novel approaches to combat biofilm drug tolerance, next-generation synthetic gene networks, engineering scalable biological systems, vaccinology, and prokaryotic gene clusters, among other topics.
Our study revealed cellular and molecular mechanisms within our bodies that enable us to develop resistance to this medication, or what scientists call drug tolerance," she added.
The results identify both a mechanism and a potential therapy for drug tolerance that is induced in the TB bacteria by the host cells they infect.
Relatively high ratios of parent to metabolite drug concentrations, suggestive of naive or intermittent drug use, where significant development of drug tolerance would be unexpected, were also used to assess the role of these pharmaceuticals in causing death.
This phenomenon, known as drug tolerance, marks the development of physical dependence on the drug.
Folic acid may also benefit individuals who use the cardiovascular drug nitroglycerin by preventing drug tolerance (decreased efficacy with use).
Drug tolerance in biomembranes: A spin label study of the effects of ethanol.
In the current analysis of classic conditioning with regard to the phenomenon of drug tolerance, there is empirical evidence of interoceptive pharmacologic cues and of exteroceptive cues, which are associated with the effect of the drug.
Using a feature-positive discrimination training, we evaluated the contribution of contexts as occasion setters of the ataxic effect of ethanol in rats The results suggest that the context acquire occasion setter properties of the drug tolerance, and that these properties can be extinguished.
Results presented at the American Society of Clinical Oncology annual meeting in Chicago, IL, on the clinical activity of amonafide dihydrochloride confirm that genotyping of patients prior to treatment allows for optimized dosing and improved drug tolerance.