cadherin

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cadherin

[kad′hir·en]
(cell and molecular biology)
Any of a family of calcium-dependent cell adhesion glycoproteins that play a fundamental role in tissue differentiation and structure.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Figure 4: Overexpression of NDRG2 in LNCaP cells increased the expression of E-cadherin (A) and decreased the expression of TGF-[BETA], Slug, Snail, and VEGF (B), significantly.
Expression of integrins E-cadherin in cells from menstrual effluent, endometrium, peritoneal fluid, peritoneum, endometriosis.
The anti-metastatic activity of BHS-I was found to be associated with inhibition of STAT3 activation at tyrosine705 (Tyr705), decreased expression of COX-2, MMP-2, MMP-9, and N-cadherin and increased expression of E-cadherin.
The semiquantitative evaluation results of cyclin [B.sub.1] and [D.sub.1] and E-cadherin are shown in Table 1.
The researchers believe that this is because the cancer cells are able to take hold in liver tissue and to colonize the organ due to close cell-to-cell contacts established with the help of E-cadherin. By altering the presence of E-cadherin, the research team was able to control the metastasis process in mice.
In comparisons performed between the groups, the pattern of positive staining with E-cadherin was found to be statistically higher in Group 3 compared with Groups 1 and 2 (p=0.003).
RNA quantification assay [Figure 3]a and Western blot analysis [Figure 3]b methods revealed there to be reduced E-cadherin and increased N-cadherin and vimentin in the collected prostatic tissues from patients with BPH and normal prostatic tissues, suggesting the involvement of EMT in the pathogenesis of BPH.{Figure 3}
The aim of the present study was to evaluate E-cadherin, Slug and NCAM expressions in GH-secreting pituitary adenomas and their relationship to the degree of tumor invasiveness.
Emerging literature suggests that EMT plays a crucial role in tumor cell metastasis and invasion, which is accompanied by upregulation of mesenchymal-associated genes such as vimentin and downregulation of epithelial-associated markers such as E-cadherin [19,20].
And Snail is targeted by miR-30a, one inducer of EMT, which is considered the transcriptional suppressor of E-cadherin, which is also involved in cell invasion and migration [47, 49].