Epstein-Barr virus

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Epstein-Barr virus

(EBV), herpesvirus that is the major cause of infectious mononucleosismononucleosis, infectious
, acute infectious disease of older children and young adults, occurring sporadically or in epidemic form, also known as mono, glandular fever, and kissing disease. The causative organism is a herpesvirus known as Epstein-Barr virus.
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 and is associated with a number of cancers, particularly lymphomaslymphoma, non-Hodgkin's,
any cancer of the lymphoid tissue (see lymphatic system) in which the Reed-Sternberg cells characteristic of Hodgkin's disease (the other category of lymphoma) are not present.
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 in immunosuppressed persons, including persons with AIDS. Epstein-Barr is a ubiquitous virus, so common that it has been difficult to determine whether it is the cause of certain diseases or whether it is simply there as an artifact. In Third World nations, most children are infected with EBV; in most industrialized nations, about 50% of the people are infected. Research has found that all of the lymphomas associated with AIDS and most lymphomas in other immunocompromised persons are connected with latent EBV infection. EBV has been found in biopsy tissue of patients with Hodgkin's diseaseHodgkin's disease,
a type of cancer of the lymphatic system. First identified in 1832 in England by Thomas Hodgkin, it is a type of malignant lymphoma. Incidence peaks in young adults and the elderly.
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, breast cancer, and some smooth muscle tumors. EBV also was formerly suspected as the cause of chronic fatigue syndromechronic fatigue syndrome
(CFS), collection of persistent, debilitating symptoms, the most notable of which is severe, lasting fatigue. In other countries it is known variously as myalgic encephalomyelitis (ME), chronic fatigue and immune dysfunction syndrome, and postviral
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 (originally named chronic EBV syndrome).

Epstein-Barr virus

An antigenically distinct member of the herpesvirus group of viruses, whose genome is DNA. EB virus is the cause of one benign disease (infectious mononucleosis), and is associated with certain types of cancer; however, the great majority of EB virus infections are clinically inapparent. The virus was detected initially by electron microscopy in a small proportion of cells in continuous lymphoblastoid cell lines derived from Burkitt's lymphoma (but particles have not been seen in cells of the tumor itself). The virus also has been detected in cell lines derived from nasopharyngeal carcinomas, a type of cancer found with high frequency in persons from southern China. The virus is found in peripheral blood leukocytes from normal individuals and from patients with infectious mononucleosis. See Infectious mononucleosis, Lymphoma

If EB virus is indeed confirmed as having a role in the development of human malignancies, then one major question to be resolved is how a virus so ubiquitous can be involved in so wide a variety of responses. However, it should be recalled that many virus infections (for example, polio virus, hepatitis viruses, certain of the arboviral encephalitides) have a wide spectrum of outcomes, ranging from inapparent infection to severe syndromes. See Animal virus

Epstein-Barr virus

[¦ep·stīn ¦bär ‚vī·rəs]
(virology)
Herpeslike virus particles first identified in cultures of cells from Burkett's malignant lymphoma.
References in periodicals archive ?
Individuals infected by this unique EBV strain have 11 times higher risk for developing NPC than the non-carriers.
Assuming prediction error cov(EBV, GEBV) is zero, the correlation between EBV and GEBV can be shown as:
These methods have equivalent sensitivity for detecting EBV in formalin-fixed, paraffin-embedded specimens of native livers from immunocompetent patients.
A preference of lower trough levels of tacrolimus in the recent years, full awareness of PTLD signs and symptoms, close monitoring of the EBV viral load, and adjustment of immunosuppressant blood levels accordingly may lead to a decrease in the incidence of PTLD worldwide and also at our center (1,7).
However, when EBV infections occur, something unusual happens.
EBV enfeksiyonu tablosuyla beraber miyoklonik tarzda nobetler goruldu, status tablosu gelisti ve EEG' de jeneralize diken dalga aktivitesi ortaya cikti.
Thus far, the highly targeted EBV proteins for both therapy and vaccine development are LMP1, LMP2, and EBNA1.
Chan et al., "Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP," PLoS Biology, vol.
Immunohistochemistry of the abnormal B-cells was positive for CD20, Bcl-2, Bcl-6, MUM1, Ki-67 (at least 90%), and EBV latent membrane protein 1 (EBV LMP-1) (Figure 3).
Con el objeto de incrementar el conocimiento respecto a la patogenesis y etiologia de los linfomas en caninos y su posible relacion con el EBV, en este trabajo se evaluo la presencia del EBV en diferentes tipos de linfomas en perros de distintas edades, razas y generos.
EBV is a DNA enveloped virus belonging to Herpes virus family.
Members of the herpesvirus family including herpes simplex virus (HSV) type 1 and 2, varicella-zoster virus (VZV), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) are distributed worldwide.