A given blood sample, processed with the AdnaTest OvarianCancer, was considered CTC positive if at least one of the tumor-associated transcripts EPCAM
, MUC1, or MUC16 was detectable with an amplicon concentration above the indicated diagnostic threshold (>0.
Those markers include von Hippel-Lindau tumor suppressor (pVHL), placental S100 (S100P), mammary serine protease inhibitor (maspin), insulin-like growth factor II messenger RNA binding protein-3 (IMP3), mesothelin, prostate stem cell antigen (PSCA), annexin A8, fascin, claudin 4, claudin 18, p53, SMAD family member 4 (DPC4/SMAD4), carcinoembryonic antigen (CEA), cytokeratin (CK) 17, CK19, mucin (MUC) 1, MUC2, MUC5AC, cancer antigen 19-9 (CA19-9), and EPCAM
coli); MSH2, DNA mismatch repair protein Msh2; MSH6, mutS homolog 6; PMS2, Mismatch repair endonuclease PMS2; EPCAM
, epithelial cell adhesion molecule.