Green's optimism about the immediate importance of embryo (and by extension ES cell
research) is shared by several contributors to the Holland-Lebacqz-Zoloth volume, most notably in chapters by Thomas O'Karma, the president of Geron Corporation, and James Thomson, whose Wisconsin group first isolated ES cell
lines in 1998.
BioTime's Singapore subsidiary, ES Cell
International Pte Ltd, has been at the forefront of advances in human embryonic stem ("hES") cell technology, being one of the earliest distributors of hES cell lines to the research community.
Although there is no published record of ES cell
research in Oman, stem cell transplantation (bone marrow, peripheral blood, and cord blood) has been carried out at Sultan Qaboos University Hospital (SQUH) since 1995.
Through technology license agreement with San Diego Regenerative Medicine Institute, Xcelthera Inc has become the first in the world to hold the proprietary breakthrough technology for large-scale production of high quality clinical-grade pluripotent human ES cell
lines and their functional human neuronal and heart cell therapy products for commercial and therapeutic uses.
The vast majority of scientists believed that nuclear reprogramming would require the use of early ES cells
, via nuclear transfer or cell fusion.
Country: IsraelSector: BiotechnologyTarget: Cell Cure Neurosciences LtdBuyer: ES Cell
International Pte Ltd, BioTime IncDeal size in USD: 3.
The safety of their use has not been proven unequivocally and there are concerns that these 'old' re-programmed somatic cells may not behave identically to their 'young' ES cell
medium was composed of KnockoutTM high glucose DMEM (Invitrogen) supplemented with 11.
Two weeks after surgery the apomorphine test was performed and then each experimental model received an injection of 5 [micro]l of ES cell
suspension (Experimental group) or medium (Control group) into the left striatum (L-3 mm, AP +9.
CHDI and its collaborators have developed a unique series of 20 ES cell
lines from genetically modified mouse models that mimic aspects of Huntington's disease.
Stem cell research became more promising as human ES cell
lines were shared and new lines were derived, more research groups were focusing attention on the differentiation of cells in vitro.
This comprehensive collection of appropriate protocols takes the novice into consideration as contributors closely describe obtaining and culturing human ES cells
, including explanations of derivatives of human ES cell
lines as well as standard and chemically-defined culture methods, characterization of human ES cells
, including phenotype, genetic and epigenetic analysis, manipulation in vivo and in vitro of human ES cells
, including differentiation and repopulation, directed differentiation of human ES stem cells into ectoderm with forebrain and other neurons, and other issues such as gene targeting and RNA interference.