embryonic stem cell

(redirected from ES cells)
Also found in: Medical.

embryonic stem cell

[‚em·brē¦än·ik ′stem ‚sel]
(embryology)
Undifferentiated cell derived from the inner cell mass of the blastocyst that can give rise to any of the three embryonic germ layers, and thus can form any cell or tissue type of the body, but cannot give rise to the full spectrum of cells required to complete fetal development.
References in periodicals archive ?
Interestingly, they also exhibited a strong expression of NANOG and OCT4, two critical transcription factors directing self-renewal and pluripotency of ES cells, in PDL-MSCs.
Our study demonstrates the sensitivity of ES cells to chronic hypoxia in the context of the dephosphorylation of ERK and Akt with the possible involvement of ROS-dependent mechanisms.
However, ES cells, irrespective of the means through which they are derived, are the source of much controversy, since their isolation is interpreted by some as necessitating the destruction of life.
As a result of the discussions in Jordan, in January 2014 the country passed a law to control research and therapy using human ES cells. The regulation was the first in the Arab and Islamic region.
One ethical issue that is applied to ES Cells is also used against iPS cells, which is the scenario evocative of science fiction; although iPS cells don't come from embryos, a scientist could induce the infinitely versatile cells to form sperm and eggs, and they might even cross the gametes in a laboratory dish to study aspects of human genetics.
We hypothesized that if angioblast-like cells could be obtained from iPS or ES cells, these cells would operate like EPCs and restore numerous impairments in DPN.
When cultured under standard human ES cell culture conditions, the morphology of SBI human iPSCs is identical to that of human ES cells.
We could then compare reset human cells to genuine mouse ES cells, and indeed we found they shared many similarities."
ES cells are not suited to repairing damaged or diseased tissue.
Xcelthera proprietary PluriXcel technology allows efficient derivation of clinical-grade human ES cell lines and direct conversion of such pluripotent human ES cells by small molecule induction into a large commercial scale of high quality human neuronal or heart muscle cells, which constitutes clinically representative progress in both human neuronal and cardiac therapeutic products for treating neurodegenerative and heart diseases.
Development of mouse embryonic stem (ES) cells [1, 2] provided much of the technology for culturing ES cells derived from blastocysts.