beta-lactamase

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beta-lactamase

[¦bād·ə ′lak·tə‚mās]
(microbiology)
A bacterial enzyme that catalyzes the hydrolysis of the lactam ring in some penicillin antibiotics, rendering them ineffective.
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The objective of this study was to compare and evaluate the efficiency of the NBPC30 and the NBC41 in the identification of ESBLs against the gold standard method.
Among the 149 ESBL producers, 50 isolates though showed zone difference of >5mm in phenotypic confirmatory test, the combination with clavulanic acid did not enhance the zone to completely susceptible levels.
Detection of extended-spectrum beta-lactamases in members of the family Enterobacteriaceae: comparison of the MAST DD test, the double disk and the Etest ESBL.
pneumoniae (n=57) collected between February and July 2006 at Sanjay Gandhi Postgraduate Institute of Medical Sciences, a tertiary care hospital in north India, were examined phenotypically for ESBL production.
Professor Pat Troop, also from the HPA, said: 'Cases of ESBL are occurring in hospitals and the communities.
Amplification of TEM, SHV and CTX-M-type ESBL genes was performed on GeneAmp PCR System 9700 (Applied Biosystems, Foster City, CA, USA) with primers and cycling conditions given in Table I (10).
Dr Dugald Baird, consultant microbiologist at Hairmyres, published the report on ESBL for the Scottish Centre for Infection and Environmental Health.
A new report released yesterday found 41 Scottish patients were infected by the ESBL bacteria between July 2001 and April this year.
He said the bug was resistant to normal antibiotics, but stressed that there was no evidence to suggest that the 41 Hairmyres patients with ESBL had actually caught the bug in the hospital.
We confirmed phenotypic ESBL using disk diffusion tests (11).
Detection of TEM and SHV genes by molecular methods in ESBL producing bacteria and their pattern of antimicrobial resistance can provide useful information about its epidemiology and risk factors associated with these infections.