beta-lactamase

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beta-lactamase

[¦bād·ə ′lak·tə‚mās]
(microbiology)
A bacterial enzyme that catalyzes the hydrolysis of the lactam ring in some penicillin antibiotics, rendering them ineffective.
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9%) that harbored CTX-M-15 gene were found to be ESBL producers [Figure 1].
In phenotypic ESBLs screening by chromogenic agar plate method, 79% (85 of 108) were found as ESBL positive; 42% (36 of 85) was E.
In Pakistan the first third generation cephalosporin resistant Shigella flexneri was isolated in The Aga Khan University Hospital, Karachi, Pakistan, in 2005, but it was not ESBL producer8.
Samples were phenotypically resistant to extended spectrum cephalosporins, but were genotyped at Seattle Children's Hospital to determine if the resistant strain was ampC or an ESBL.
ESBL Detection: (i) Double Disc Method: The isolates presumed to be ESBL producers were inoculated on the Muller Hinton agar plate.
As there was not detected ESBL, it is concluded that the mechanisms of resistance may be produced by means of altered PBP that reduce affinity to [beta]-lactam antibiotics as well as the synergy between reduced drug intake and active efflux pumps.