TEL

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TEL

(organic chemistry)

TEL

On drawings, abbr. for “telephone.”
References in periodicals archive ?
Apart from chromosome 5, ETV6 has also been found to fuse with other genes in different chromosomes like AML1 in acute lymphoblastic leukemia (ALL), with ABL or JAK2 in early pre-B-cell ALL, with MN1 in MPD, with MDS1/EVI1 in MPD, and with STL in a B-cell ALL cell line [7].
Outside of the salivary glands, ETV6 rearrangements can be detected in tumors arising from all embryologic layers.
Cell block preparations made from cytology specimens have proved adequate at demonstrating S100 protein and mammaglobin expression by immunohistochemistry and the ETV6 gene rearrangement by fluorescence in situ hybridization (FISH).
77,84,96-98) In contrast, mutations in TP53, EZH2, ETV6, RUNX1, and ASXL1 are predictors of poor overall survival in patients with myelodysplastic syndromes, independently of established risk factors.
Gene Aberrations Associated with Prognosis of Myelodysplastic Syndrome (MDS) Gene Group Gene Frequency Prognostic Value in MDS, % in MDS Transcription factor ETV6 12 Adverse and cofactors RUNX1 10-20 Adverse Signal transduction NRAS 9 Adverse proteins CBL 12 Adverse Epigenetic regulators TET2 19-26 Controversial EZH2 12 Adverse DNMT3A 2.
72) Particularly relevant are cases of t(5;12)(q33;p13), in which PDGFRB is activated by fusion with ETV6.
12) The isodicentricity of chromosome 12 resulted in loss of 12p13, the locus of the ETV6 gene (also known as TEL1).
The ETV6 gene located on chromosome 12 encodes an E26 transformation-specific transcription factor, and the resulting ETV protein is expressed in healthy breast epithelial cells.
Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25).