ectopic expression


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ectopic expression

[ek¦täp·ik iks′presh·ən]
(genetics)
Phenotypic expression of a gene in a type of cell or tissue in which it is usually inactive.
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Interestingly, our results showed that ectopic expression of HtrA1 inhibited the mRNA expression of Notch-1 in PANC-1 cells (Figure 4A).
Up to now, several cell-targeting strategies have been developed to obtain the efficient mechanism for delivery of an interested gene to a particular target cell and operating its ectopic expression in vitro.
This explains nicely why in a genome wide analysis of expression, genes are both repressed and activated when a transcription factor is either added (ectopic expression) or taken away (loss of function).
As shown in Figures 3(c) and 3(d), ectopic expression of GBP1 did not promote the migration of PDLSCs, but it further enhanced the migration activity of PDLSCs in presence of IFN-[gamma] at a concentration of 10 ng/ml.
In contrast, ectopic expression of miR-21 in FLS was found to increase nucleoprotein NF-[kappa]B levels and cell proliferation rates, further validating that miR-21 could promote FLS proliferation by facilitating NF-[kappa]B nuclear translocation, consequently affecting the function of the NF-[kappa]B pathway in RA FLS.
We confirmed that ectopic expression of miR-128 through pCMV-miR-128 (of about 100 folds at 24 h posttransfection, Supplemental Figure S1) in HEK293 cells indeed reduced the luciferase activity of the MAFG-3UTR reporter construct while there was no effect on the Nrf2-3UTR construct, very similar to the results obtained with synthetic pre-miR-128 (data not shown).
It was found that ectopic expression of miR-31 induced early apoptosis in these two gastric cancer cells (Figures 3(a) and 3(b)).
Ectopic expression of a tomato 9-cis-epoxycarotenoid dioxygenase gene causes overproduction of abscisic acid.
The ectopic expressions of Dab2 were observed in several human malignant cancer cell lines: Data pooled from eight studies in this meta-analysis showed that the ectopic expression of Dab2 were observed in 17 human malignant cancer cell lines, including: A549, LTE, H1299, SH-SY5Y, HT1080, et al.
Similarly, ectopic expression of miR-137 in A549, NCIH460, and NCI-H520 resulted in G1 cell cycle arrest [65].
Conversely, LincRNA-EPS ectopic expression by retroviral transduction was able to prevent apoptosis in erythroid cells starved for erythropoietin (Epo), an essential prosurvival and differentiating cytokine of the erythropoiesis system, even if it did not restore the terminal differentiation, as determined by the levels of haemoglobin.
Importantly, miR-30d ectopic expression in an ATC cell line reduced monolayer cell growth and impaired anchorage-independent cell growth [30].