Elastase


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elastase

[i′la‚stās]
(biochemistry)
An enzyme which acts on elastin to change it chemically and render it soluble.

Elastase

 

an enzyme of the hydrolase class elaborated by the pancreas of animals including humans. Elastase catalyzes the splitting of peptide bonds in proteins, chiefly those between the radicals of neutral animo acids. It is particularly active against elastin. The enzyme is secreted in the form of inactive proelastase, which is converted to elastase by the enzyme trypsin. Elastase is found in some bacteria.

References in periodicals archive ?
Although a relationship between ELA2 mutations and SCN has been shown, mice deficient in elastase had normal granulopoiesis, suggesting that these mutations cause a gain rather than a loss of function [12].
Whether the combination of fecal pancreas elastase 1 as a marker of exocrine pancreatic insufficiency and mutant K-ras, which are both independent predictive factors for pancreatic cancer development in patients with chronic pancreatitis (17), may be useful remains to be clarified by further studies.
He began collaborating with the Virginia medical group and in 1999 developed a way to chemically modify cotton gauze so that it selectively targets and soaks up elastase.
The experimental oral elastase inhibitor, developed by Zeneca Pharmaceuticals (Wilmington, DE) has thus far been studied only in mice which have been inoculated with a myocarditis virus.
Early results demonstrating that CTX-4430 can reduce elastase and sputum neutrophils are promising.
The homogenate was centrifuged at 3000 x g for 5 min to estimate TBARS and GSH and at 12,000 x g for 5 min, and resultant PMS was used to carry out elastase, MPO, catalase, SOD and NO assay, the resulting supernatant was stored at -80[degrees]C until further analysis.
Research has shown that ceramides derived from wheat inhibit the elastase enzymes that destroy the skin's elastin, which results in loss of flexibility and increased wrinkling.
In-vitro enzymatic degradation was performed using collagenase, elastase and trypsin enzymes.
The balance between the MMPs, such as matrix collagenase, elastase, geratinase, hyaluronidase and others and their inhibitors is disrupted.
Elastase is an enzyme associated with the deterioration of elastin, a protein that is a vital part of elastic fibers in the skin.
Andrew Wilson, lead author of the study and an assistant professor of medicine at BUSM, said: "The progression of emphysema in mice exposed to elastase was significantly improved by the gene therapy as evidenced by improvements in lung compliance and alveolar size.