electrophilic

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electrophilic

[i¦lek·trō′fil·ik]
(physical chemistry)
Pertaining to any chemical process in which electrons are acquired from or shared with other molecules or ions.
Referring to an electron-deficient species.
References in periodicals archive ?
However, one can detect adducts formed from reactions between reactive electrophiles and nucleophilic residues on DNA and proteins.
42) Thiolate is highly nucleo-philic and thus is more susceptible to electrophiles and oxidizing agents than thiol, conferring the protein with the sensitivity to detect changes in the redox status and other physicochemical parameters.
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keapl sensor modified by inducers.
Keap1 is rich in cysteine residues (27 cysteine residues in human) which can be modified by several antioxidants and electrophiles.
It is ubiquitous tripeptide produced by most mammalian cells and it is the main antioxidant defense against ROS and electrophiles.
With the strong acid sites in the poly hydroxyl layer of nCOP, electrophiles could be effectively activated at the curing temperature (Fig.
Glutathione-S- transferase belonging to the detoxification system for Phase II cytosolic enzyme which catalyzes the conjugation of reduced glutathione to a variety of exogenous or endogenous electrophiles [16 and 18].
First, the initiating carcinogens in tobacco which act as reactive electrophiles (having electron deficient atoms) react with nucleophilic (electron rich) sites in the cell.
Other topics are molecular structure and reactivity, general principles for writing reaction mechanisms, reactions of nucleophiles and bases, reactions involving acids and other electrophiles, radicals and radical ions, and pericyclic reactions.
Sulforaphane is an isothiocyanate derived from broccoli with therapeutic potential based on its activity to up-regulate genes that influence an aerobic cell's ability to protect against oxidative stress, inflammation, DNA-damaging electrophiles, and radiation.
47) Furthermore, a recent study in cultured liver cancer cells (48) showed that chlorophyllin was one of the most potent inducers of a set of enzymes that protect the cells against potentially harmful oxidants and electrophiles, two types of unstable molecules that damage tissues and contribute to cancer.
Hydroxyl radicals (HO*) are effective in destroying organic chemicals because they are reactive electrophiles (electron-preferring species) that react rapidly and non-selectively with nearly all electron-rich organic compounds.