biological half-life

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biological half-life

[¦bī·ə¦läj·ə·kəl ′haf ‚līf]
(physiology)
The time required by the body to eliminate half of the amount of an administered substance through normal channels of elimination.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Distribution half life according to two compartmental model was 0.12 +- 0.10 hours and Elimination half life was 1.91 +- 0.95 hrs.
Prolonged elimination half life and associated complications warrant for rational prescribing and long term follow up.
A lower absorption half life value in the diabetic rabbits suggest quick absorption of the drug, where as the value for elimination rate constant increased significantly in the diabetic rabbit that is (83.33%) resulted in a shorter elimination half life i.e.
The standardized ethanolic extract of Vitex negundo was orally given along with paracetamol to albino rats and pharmacokinetic changes were investigated in terms of AUC (area under curve), [C.sub.max] (maximum plasma concentration), [T.sub.max] (time to reach maximum plasma concentration ), [K.sub.e1] (elimination rate constant), [t.sub.1/2] (elimination half life), RB% (relative bioavailability ) of paracetamol.
The concentration declined with a mean elimination half life of 5.97 [+ or -] 0.95 h.

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