biological half-life

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biological half-life

[¦bī·ə¦läj·ə·kəl ′haf ‚līf]
(physiology)
The time required by the body to eliminate half of the amount of an administered substance through normal channels of elimination.
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Prolonged elimination half life and associated complications warrant for rational prescribing and long term follow up.
and absorption half life occurred between the normal and diabetic rabbits, where as elimination rate constant, absorption rate constant were increased, and distribution half life and elimination half life decreased significantly.
Conclusion: Elimination half life of nearly six hours suggests that the drug needs to be given orally at the interval of six hours.
h/l) Cmax ([mu]mol/l), volume of distribution assuming full bioavailability (V) (1/kg), clearance assuming full bioavailability (ml/min/kg) and elimination half life (t1/2z) (h) values in 12 young and 12 elderly volunteers after dosing with approximately 40mg/kg body weight of aspartame--statistical comparisons were made using Students' unpaired t tests with two-tailed tests of significance Group Minimum Maximum Mean SD p value AUC Young 216.
The data demonstrated pharmacokinetics of inhaled liposomal ciprofloxacin with a long systemic elimination half life (t u ) of ~10.
11) Moxifloxacin is slowly eliminated with an elimination half life of 2.

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