biological half-life

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biological half-life

[¦bī·ə¦läj·ə·kəl ′haf ‚līf]
(physiology)
The time required by the body to eliminate half of the amount of an administered substance through normal channels of elimination.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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The value of elimination half-life (t1/2[beta]) of warfarin (0.5 mg.kg-1) in the absence and presence of caffeine was 34.1+-4.8 hr 49.1+-2.4 hr, respectively and were found to be significant.
The apparent elimination half-life ([t.sub.1/2]) was calculated as 0.693/[[lambda].sub.z].
The blood elimination half-life of [C.sub.8] PFPA (determined to be <1 d; Table 1) aligns with the faster disappearance of PFPAs compared with 1H-PFAs in blood.
The elimination half-life and elimination rate constant after oral administration of atorvastatin was calculated as 6.14 3.47 hours and 0.15 0.10 l/hr respectively.
Although the animal data, molecular weight (about 868), and elimination half-life (about 26 hours) suggest embryo-fetal risk, the high plasma protein binding (99.9%) should limit the amount crossing the placenta.
The mean elimination half-life of nanoparticle DQ in the liver was observed to be 861.16 hours after a single IM injection.
The area under the curve (AUC), peak times ([T.sub.max]), peak plasma concentrations ([C.sub.max]), elimination half-life ([T.sub.1/2]), and absolute bioavailability (F) were calculated for pharmacokinetic determination using a noncompartmental analysis.
It also has a very rapid metabolization profile, with an elimination half-life of 3-7 hours.
Factor altering its half-life include patient age, duration of lithium therapy and level of renal function.8 Lithium has an elimination half-life of 12 to 27 hours after a single dose but its elimination half-life can increase to as long as 58 hours in elderly individual or patient taking lithium chronically.8 Thus, one must measure lithium levels several times after a toxic ingestion, because its rate of illumination is variable and cannot be predicted in any given patient.
The postulated mechanism of meperidine-associated seizures is related to its active metabolite normeperidine that has half of the activity of meperidine and a longer elimination half-life (8–12 h), therefore, cause excitation of the central nervous system and lead to nervousness, hyper-reflexia, myoclonus, and seizures.
Tissues: The elimination half-life of cefpirome different tissues are depicted in Table 2.

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