biological half-life

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biological half-life

[¦bī·ə¦läj·ə·kəl ′haf ‚līf]
(physiology)
The time required by the body to eliminate half of the amount of an administered substance through normal channels of elimination.
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The values for elimination rate constant, elimination half-life, and MRT were 0.
Although the animal data, molecular weight (about 868), and elimination half-life (about 26 hours) suggest embryo-fetal risk, the high plasma protein binding (99.
In those patients, the elimination half-life can be increased up to 13 hours.
Elimination half-life of cefpirome in lungs was highest followed by heart, liver, kidney, and spleen while its plasma half-life [t.
Additionally, the elimination half-life of some drugs may increase with age because of larger volumes of distribution and reduction in hepatic or renal clearance.
The elimination half-life of diazepam after oral administration is about 21-37 hours in healthy individuals.
The findings suggest that a high dose of caffeine does not adversely affect PTP or PPE measures during the timeline examined (a total of five hours beginning with the consumption of the first beverage--within the elimination half-life of caffeine).
psychiatrists), particularly about switching from a psychotropic drug with a short elimination half-life to a similar psychotropic drug with a longer elimination half-life prior to tapering.
The short elimination half-life and MRT were observed in donkeys when compared with horses, dogs, rats and human.
It is well known that rocuronium in patients with liver dysfunction exhibits a longer onset in addition with prolonged elimination half-life (2), as occurred in our patients.
There is an association between paclitaxel 's elimination half-life and the time to platelet recovery in cases of drug-induced thrombocytopenia (5), (6).

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