The second step of the evaluation circuit of Thalidomide will be that the Diagnostic Units receive this request and, once in their hands, they will analyze whether the cases are compatible with the thalidomide embryopathy
, writing an interim report that will be posted for this purpose.
Schuler-Faccini L, Ribeiro EM, Feitosa IM, Horovitz DD, Cavalcanti DP, Pessoa A, Doriqui MJ, Neri JI, Neto JM, Wanderley HY, Cernach M, El-Husny AS, Pone MV, Serao CL, Sanseverino MT, Brazilian Medical Genetics Society-Zika Embryopathy
This results in a 4-10% risk of warfarin embryopathy
6) Many authors have also suggested hereditary involvement as an autosomal dominant trait with reduced penetrance, trauma and environmental factors such as thalidomide, embryopathy
, fetal alcohol exposure or hypervitaminosis.
ranges from craniofacial dysmorphias appendagial abnormalities to meningoencephaloceles.
These types of malformations have been grouped in a fairly specific embryopathy
called fetal valproate syndrome.
Septo-optic dysplasia as a manifestation of valproic acid embryopathy
AMP-activated protein kinase mediates effects of oxidative stress on embryo gene expression in a mouse model of diabetic embryopathy
Neuropathy to embryopathy
, with case reports of congenital anomalies.
Reporting bias in retrospective ascertainment of drug induced embryopathy
A case of methotrexate embryopathy
with holoprosencephaly, expanding the phenotype.
The chief risk posed by use of the drug in women of childbearing potential is retinoid embryopathy
, which occurs in 33% of preterm infants exposed to the drug in utero.