George Emil Palade

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Palade, George Emil

(pälä`dē), 1912–2008, American cell biologist, b. Iaşi, Romania, M.D. Univ. of Bucharest, 1940. He was a faculty member at the Rockefeller Institute (now Rockefeller Univ.) from 1946 to 1973, when he joined the Yale Medical School. From 1990 until 2001, when he retired, he was at the Univ. of California, San Diego, where he was the medical school's dean for scientific affairs. in Palade received the 1974 Nobel Prize in physiology or medicine with Albert ClaudeClaude, Albert
, 1899–1983, Belgian biologist, b. Longlier, M.D., Univ. of Liège, 1928. He joined the Rockefeller Institute (now Rockefeller Univ.) in 1929 and spent his entire career there.
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 and Christian de Duvede Duve, Christian
(Christian Renē Maria Joseph de Duve), 1917–2013, Belgian cell biologist, b. England, M.D., Catholic Univ. of Louvain, 1941. He joined the faculty at Louvain in 1947 and at the Rockefeller Institute (now Rockefeller Univ.
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 for contributing to knowledge about the structural and functional organization of the cell. He combined two techniques pioneered by Claude for biological applications—electron microscopy and differential centrifugation—to discover basic morphological information about ribosomes and other elements of cell biology. Palade's work led to an understanding of the cell as a sophisticated system rather than a collection of components whose functions were unknown.

Palade, George Emil

 

Born Nov. 19, 1912, in Iaşi, Rumania. American biologist and cytologist. Member of the National Academy of Sciences and the American Academy of Arts and Sciences.

Palade graduated from the University of Bucharest. He worked at the Institute of Anatomy in Bucharest until 1946, when he emigrated to the United States. He was head of the department of cell biology of the Rockefeller Institute for Medical Research from 1946 to 1973. In 1973 he became a professor and department head at Yale University School of Medicine.

Palade’s main works have dealt with electron microscopy of subcellular structures and their function in cell biology. He made a thorough study of the ultrastructure of mitochondria. In 1953 he became the first to describe ribosomes.

Palade was awarded a Nobel Prize in 1974 with A. Claude and C. de Duve. Palade is a foreign member of the Leopoldina German Academy of Naturalists.

WORKS

“The Fine Structure of Mitochondria.” Anatomical Record, 1952, vol. 114, no. 3.
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