Thus, expert panels have developed evidence-based guidelines for empirical treatment
of UTI, which requires the availability of high-quality data from surveillance studies regarding a major challenge in UTI therapy: antimicrobial resistance among uropathogens.
The infection did not respond to empirical treatment
with clindamycin and ciprofloxacin.
A review of three randomized, double-blind, placebo-controlled studies of 162 children with nonspecific, chronic cough indicates that empirical treatment
with antihistamines is not recommended in this setting, the authors concluded.
All outcomes favored PPIs over placebo, but the reviewers considered the magnitude of effect to be too uncertain to support guidelines, such as those published in 1998 by a consensus panel of the American College of Chest Physicians, suggesting empirical treatment
for reflux (Chest 1998;114:133S-81S).
Noninvasive testing for Helicobacter pylori infection followed by empirical treatment
with eradication therapy was more effective than treatment with a proton pump inhibitor alone for young adult patients with dyspepsia, reported Dr.
(3) The financial constraints limit the patient to go for serial wound cultures so as to make the clinicians be based on the empirical treatment
that itself leading to the resistant strains in the community.
A presumptive diagnosis of herpes simplex encephalitis (HSE) was made on the basis of serological and MRI findings; empirical treatment
with intravenous acyclovir 750 mg eight hourly was initiated.
pneumoniae (ESBL-KP), but this class of drugs is not always used as first option in empirical treatment
for early nosocomial infection in developing countries.
with acyclovir (2.3 g/day) was started for the first 48 hours.
(14) However, clarithromycin-susceptible and resistant strains have been isolated from patients with no history of exposure to macrolides, (18) which may suggest that administration of clarithromycin may select for the resistant strains and therefore must be guided by empirical treatment
Dalbavancin could be an alternative to vancomycin and linezolid for complicated skin and skin structure infections caused by gram-positive pathogens, and since it can be administered in outpatient settings, it might be a reasonable option for empirical treatment
of such infections suspected to be caused by MRSA, the investigators said.
An accurate diagnosis obviates the need for empirical treatment
and the associated risk of resistance.