Simultaneous determination of warfarin enantiomers
and its metabolite in human plasma by column-switching high-performance liquid chromatography with chiral separation.
127) However, in response to several cases where negative side effects were attributed to the undesired enantiomer
, (128) the FDA now requires data pertaining to the individual enantiomers
of a chiral drug.
Moreover, he found that a PHOSITA had no way of knowing what the properties of the d-enantiomer
and its salts would be without testing the individual combinations; therefore, the beneficial properties of clopidogrel were not known before the racemic mixture was separated into its enantiomers
For all analytes except S-(+)-MA and the 2 enantiomers
of MDEA, the corresponding enantiomers
of the deuterated analogs were used as IS.
Determining the handedness of a given molecule is of utmost importance in chiral studies, and VCD is a technique for determining this characteristic that does not require the addition of foreign samples or the separation of enantiomers
What effects citalopram has on cytochrome P-450 enzyme systems (for the most part mild) are attributable to the R-citalopram enantiomer
Revlimid, the commercial form of lenalidomide, contains a racemic (1:1) mixture of R and S enantiomers
that interconvert in vivo.
They predicted that enantiomers
characterized by the so-called rotational chirality will rotate the plane-polarized light, i.
Chiral separation chromatography is a technique involving two enantiomers
of the same compound with different affinities for the stationary phase consisting of a single enantiomer
, thus possessing different elution times.
By convention the enantiomers
with opposite stereochemistry around the chiral centres are designated ephedrine, while pseudoephedrine has same stereochemistry around the chiral carbons.
This was an unanticipated result, since it is not very common to find the opposite enantiomers
(left- and right-handed forms) of the same compound among the secondary metabolites of related species," he added.
In addition, enantiomers
of 1 were separated and the respective enantiomers