Those issues come up with particular frequency in cases involving
enantiomers and other efforts to modify a known chemical compound in well-understood ways.
1981) Chromatographic resolution of
enantiomers having aromatic group by optically active poly(triphenylmethyl methacrylate).
When polymer is exposed to a racemate solution the polymer adsorbs one of the
enantiomer with notable selectivity [7 8].
The two linalool
enantiomers were identified by both retention time and corresponding mass spectra (results not shown).
Baseline resolution of the 6
enantiomers from an [alpha]-, [beta]-, and [gamma]-HBCD mixture was achieved on [beta]-permethylated cyclodextrin bonded (NUCLEODEX, Macherey-Nagel, GmbH, Diiren, Germany) chiral LC column (4 x 200 mm, 5[micro]m) [96].
Pharmacokinetics and pharmacodynamics of ketoprofen
enantiomers in the horse.
The effect of bilobalide on the decrease in plasma concentration of warfarin
enantiomers was clearer for the (R)-isomer than for the (S)-isomer.
The natural
enantiomer of the RNA precursor molecules formed a crystal structure visible to the naked eye.
In addition, the (+) -
enantiomer inhibits sero-tonin uptake and the (-) -
enantiomer is a potent no-radrenaline inhibitor, complementary properties which result in a synergistic antinciceptive interac-tion between the two
enantiomers.
The two
enantiomers often display different characteristics, so there is considerable financial benefit to separating them cheaply.
The animal data for vigabatrin (Sabril; C), an equal mixture of active and inactive
enantiomers, suggest risk, as do the human data.
A representative chromatogram showing resolution of derivatives of
enantiomers is shown in Fig-2.
