The highest
enantioselectivity during [delta]-lactonization was observed in the case of menthol ester 2a (enantiomeric excess (ee) 36%) and borneol 2c ester (24% ee).
An attractive alternative has been developed by taking advantage of high
enantioselectivity observed in ethylalumination and higher alkylalumination.
Hua, "A molecular modeling study on the
enantioselectivity of aryl alkyl ketone reductions by a NADPH-dependent carbonyl reductase," Journal of Molecular Modeling, vol.
As a result, high catalyst loading (25 mol%) at room temperature enables one to achieve the best value of yield, diastereoselectivity, and
enantioselectivity (entry 4).
Differential
enantioselectivity and product-dependent activation and inhibition in metabolism of verapamil by human CYP3As.
Construction and characterization of a recombinant esterase with high activity and
enantioselectivity to (S)-ketoprofen ethyl ester.
Therefore, no further
enantioselectivity improvement was performed for the following in vitro experiments.
To discuss the
enantioselectivity quantitatively, we defined the separation factor as follows: [alpha] = [K.sub.L]/[K.sub.D] or [alpha] = [K.sub.D]/[K.sub.L].
Sinou, "Influence of amphiphile concentration on the
enantioselectivity in the rhodium-catalyzed reduction of unsaturated substrates in water," Journal of Molecular Catalysis A, vol.
Despite these advantages, there is still work to be done; for example, the
enantioselectivity is still not quite as high as with the slower-acting aluminum complexes.
A privileged chiral ligand or catalyst is one that shows good
enantioselectivity over a wide range of different reactions, due to its core structure.
They have also been found useful as chiral auxiliaries, as inducers of
enantioselectivity, and as fluorescence sensors.
