The highest enantioselectivity
during [delta]-lactonization was observed in the case of menthol ester 2a (enantiomeric excess (ee) 36%) and borneol 2c ester (24% ee).
An attractive alternative has been developed by taking advantage of high enantioselectivity
observed in ethylalumination and higher alkylalumination.
Hua, "A molecular modeling study on the enantioselectivity
of aryl alkyl ketone reductions by a NADPH-dependent carbonyl reductase," Journal of Molecular Modeling, vol.
As a result, high catalyst loading (25 mol%) at room temperature enables one to achieve the best value of yield, diastereoselectivity, and enantioselectivity
and product-dependent activation and inhibition in metabolism of verapamil by human CYP3As.
Construction and characterization of a recombinant esterase with high activity and enantioselectivity
to (S)-ketoprofen ethyl ester.
Therefore, no further enantioselectivity
improvement was performed for the following in vitro experiments.
To discuss the enantioselectivity
quantitatively, we defined the separation factor as follows: [alpha] = [K.sub.L]/[K.sub.D] or [alpha] = [K.sub.D]/[K.sub.L].
Sinou, "Influence of amphiphile concentration on the enantioselectivity
in the rhodium-catalyzed reduction of unsaturated substrates in water," Journal of Molecular Catalysis A, vol.
Despite these advantages, there is still work to be done; for example, the enantioselectivity
is still not quite as high as with the slower-acting aluminum complexes.
A privileged chiral ligand or catalyst is one that shows good enantioselectivity
over a wide range of different reactions, due to its core structure.
They have also been found useful as chiral auxiliaries, as inducers of enantioselectivity
, and as fluorescence sensors.