endoglycosidase

(redirected from Endo-glycosidase)

endoglycosidase

[‚en·dō·glī′kō·sə‚dās]
(biochemistry)
An enzyme which releases intact glycans from their linkages with amino acids.
References in periodicals archive ?
Testicular hyaluronidase (hyaluronidase), which acts on hyaluronan (HA) and chondroitin sulfates (ChSs), is one such endo-glycosidase.
Three types of endo-glycosidase (endo-[beta]-glucuronidase, (27) endo-[beta]-xylosidase28) and endo-[beta]-galactosidase (29)) act on the linkage region (GlcUA-Gal-Ga1Xyl-Ser) between the core peptide and the GAG chain of a proteoglycan (Fig.
Therefore, we have employed glycotechnology for the synthesis of neoproteoglycans with long GAG chains by using glycosidases, especially endo-glycosidases.
It is likely that transglycosylation mediated by endo-glycosidases together with their subsequent coupling to a desired peptide core will open up a new field of glycotechnology for engineering GAGs.