The role of chondrocytes in intramembranous and endochondral
ossification during distraction osteogenesis in the rabbit.
The tumors arise from the cartilages (thyroid most frequently) of the larynx in areas of endochondral
ossification, with a typical histology of numerous giant cells containing many nuclei that are histologically indistinguishable from the nuclei of the stromal spindle cells surrounding the giant cells.
Deer antler does not represent a typical endochondral
growth system: immunoidentification of collagen type X but little collagen type II in growing antler tissue.
Elements (and % weight; dermal and endochondral
, respectively) of a modern specimen were:
Failure of endochondral
ossification of the skull base, vertebral bodies and long bones results in rhizomelic limb shortening (short proximal segments), macrocephaly, frontal bossing and midface hypoplasia (5).
PTHrP (Parathyroid hormone-related protein), also known as PTHLH and HHM, regulates endochondral
bone development and epithelial-mesenchymal interactions.
Stryker Corporation (Kalamazoo, MI) has patented (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral
bone formation in mammals.
They are produced by a progressive endochondral
ossification of a growing cartilaginous cap.
Rickets, one manifestation of metabolic bone disease, is a musculoskeletal disease syndromes characterized by abnormal endochondral
ossification (7) and failure of mineralization of osteoid or of the maturing cartilaginous growth plate.
5,6) The histopathology of ML II is characterized by intracytoplasmic membrane-bound vacuoles in lymphocytes and fibroblasts in various tissues such as skin, conjunctiva, lymph nodes, spleen, gingiva, heart valves, and bones in areas of endochondral
and membranous bone formation.
41) MSCs have been shown to be the primary source for endochondral
bone formation, (42) and as such are ideal for future bone repair constructs.
In a Mn-deficient animal, therefore, there can be a failure of endochondral
ossification, resulting in chondrodystrophy and perosis (Underwood and Suttle, 1999).