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An enzyme that acts upon the centrally located peptide bonds of a protein molecule.



an enzyme of the class of hydrolases. Endo-peptidases catalyze the decomposition of internal peptide bonds in proteins and peptides. The speed of hydrolysis of a given peptide bond by different endopeptidases depends on the substrate specificity of the enzyme and the spatial accessibility of the given peptide bond, especially if the substrate is a native, not denatured, protein. It does not depend on the size of the molecules of the substrate, that is, the length of the polypeptide chain. The substrate specificity of an endopeptidase consists in the ability of a given enzyme to hydrolyze the peptide bonds between certain amino acid residues with the greatest speed. For example, chy-motrypsin very rapidly hydrolyzes peptide bonds together with aromatic amino acids; trypsin does the same with diamino acids. Endopeptidases are classified as extracellular or intracellular (tissular). Extracellular endopeptidases are secreted into the digestive cavity of animals (for example, enterokinase) or simply into the external environment (the exo-enzymes of bacteria).

The use of endopeptidases in determining the primary structure of proteins is based on their properties.

References in periodicals archive ?
Aspartic cathepsin D endopeptidase contributes to extracellular digestion in clawed lobsters Homarus americanus and Homarus gammarus.
Neprilysin (NEP) [3] (neutral endopeptidase, enkephalinase, E.
Characterization of endopeptidases from the midgut of Morimus funereus (Coleoptera: CerambyCidae) larvae.
These results showed that Alcalase which is an endopeptidases can produce higher amount of peptides with smallest molecular size compared to Flavourzyme which is an exopeptidases.
In enzyme modified cheese applications, the hydrolysis of cheese proteins by endopeptidases such as animal and bacterial proteases, can give rise to unwanted bitter flavours.
2001) Neprilysin degrades both amyloid [beta] peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases.
Glutalytic contains both endopeptidases and exopeptidases to create the correct endopeptidase cleavage pattern near the long chain amino acids that need to be hydrolyzed by the exopeptidase, producing rapid degradation of gluten.
De acordo com os resultados encontrados, houve um aumento (P<0,05) linear na perda de agua por coccao (PAC) ao longo da estocagem, passando de 18,24% no primeiro dia para 28,25% apos 28 dias de armazenamento refrigerado, provavelmente devido a atividade proteolitica causada tanto pelas endopeptidases da propria carne quanto por enzimas produzidas pelos micro-organismos, ja que estes atingiram contagens bastante elevadas ([10.
These compounds are zinc-dependent endopeptidases that play an important role in the remodeling of connective tissue and are involved in embryogenesis, wound healing, rheumatoid arthritis, and tumor invasion and metastasis.
Matrix metalloproteinases encompass a family of zinc- and calcium-dependent endopeptidases secreted or released by a variety of host cells that function at neutral [p.