endosome

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endosome

[′en·də‚sōm]
(cell and molecular biology)
A mass of chromatin near the center of a vesicular nucleus.
(invertebrate zoology)
The inner layer of certain sponges.
References in periodicals archive ?
The antibody-protein pair starts out in an endosome but gets waylaid into a special compartment, Watts and his colleagues also report in the May 12 NATURE.
The formation of isolation membranes by trans-Golgi/endosomal fusion is also supported by studies showing a requirement for Rab9, which is a GTPase essential for the trafficking of proteins from late endosomes to trans-Golgi membranes.
This might occur because Cl- channels are responsible for endosome and lysosomal acidification [153], which is necessary to initiate entry fusion of HCV envelope proteins to the membrane and viral genome release [188].
These endosomes fuse with other naturally-occurring organelles termed lysosomes, which contain enzymes that serve as the digestive system of the cell.
7 cells and BEAS-2B cells proposed that the toxicity of ZnO nano-particles (13 nm) in both cell types is related to particle dissolution that could happen in culture medium and intracellular endosomes (Xia et al.
Degradation of insulin by isolated rat renal cortical endosomes.
Professor Joseph Irudayaraj and graduate student Jiji Chen, both in the Department of Agricultural and Biological Engineering, have found that the nanoprobes, or nanorods, when coated with the breast cancer drug Herceptin, are reaching the endosomes of cells, mimicking the delivery of the drug on its own.
DT is internalized by receptor-mediated endocytosis to endosomes and subsequently cleaved by a protease of the furin family within a protease-sensitive loop between the catalytic and transmembrane domains (5).
Ted Hackstadt (National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT) reported that, unlike the majority of most intracellular parasites, which block maturation of endosomes to lysosomes at discrete stages and then replicate within those vacuoles, chlamydiae appear to dissociate themselves from the endocytic pathway shortly after internalization by actively modifying the vacuole to become fusogenic with sphingomyelin-containing exocytic vesicles.
The pattern of immunostaining of intracellular A[Beta] suggests that this peptide is contained in vesicular compartments, such as endoplasmic reticulum, Golgi, endosomes, or lysosomes, all of which have been implicated in the generation of the A[Beta] peptides.
The researchers found that endosomes carrying crocidolite fibers 5 micrometers or smaller quickly begin speeding toward the cell nucleus via microtubules -- elaborate, filamentous roadways along which the cell shuttles its inner "vehicles.
In our previous work, we considered that mucolipin 1 mediated the release of endosomes and lysosome iron contributed to the increased LIP induced by ethanol [8].