enkephalin

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Related to Enkephalins: encephalitis, Endorphins, somatostatin, substance P

enkephalin

(ĕnkĕf`əlĭn), one of several naturally occurring morphinelike substances (endorphinsendorphins
, neurotransmitters found in the brain that have pain-relieving properties similar to morphine. There are three major types of endorphins: beta endorpins, found primarily in the pituitary gland; and enkephalins and dynorphin, both distributed throughout the nervous
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) released from nerve endings of the central nervous system and the adrenal medulla. They act as analgesics and sedatives in the body and appear to affect mood and motivation.

enkephalin

[en′kef·ə·lən]
(biochemistry)
A mixture of two polypeptides isolated from the brain; central mode of action is an inhibition of neurotransmitter release.
References in periodicals archive ?
Several decades ago, neuroscientists identified endorphins and enkephalins, opium-like compounds manufactured by the human brain.
The enkephalins are found mainly in those areas of the brain associated with pain control, including the periventricular area, the periaqueductal gray, the midline raphe nuclei, the substantia gelatinosa of the dorsal horns in the spinal cord, and the intralaminar nuclei of the thalamus.
In other work by George and colleagues (1991), they concluded that a relative lack of enkephalin peptides trans-synaptically, possibly resulting from enhanced enkephalin degradation, might contribute to increased alcohol consumption in C57Bl/6J mice.
The company's lead NTDDS projects include using enkephalin and GAD for chronic pain, e.
8 Pyrrolidonecarboxylate peptidase AP Peptide substrate Arylamide substrate GIuAP Ang II, Ang I, CCK (b) GIuNNap, AspNNap AspAP Ang II, Ang I, CCK AspNNap, GIuNNap ArgAP Ang III, enkephalins, neurotensin ArgNNap, LysNNap AIaAP Enkephalins, bradykinin, Ang III AIaNNap, LeuNNap CysAP OT, VP LysNNap pGIuAP TRH, GnRH, neurotensin, bombesin pGIuNNap AP References GIuAP (7.
Activation of the pain control system increases the concentration of beta endorphin, enkephalin, serotonin and norepinephrine levels in the brain tissue and plasma, thus creating an analgesic effect, as well as many others.
It seems likely that our enkephalin findings in rats mean that this neurotransmitter may drive some forms of overconsumption and addiction in people.
Endogenous opioids: A group of small molecules, such as endorphins and enkephalins, that are naturally produced in the body and which have similar effects as the opiates (e.
It therefore elicits an analgesic effect wherever enkephalins are produced as a response to a painful stimulus, and maintains a high level of these natural analgesic substances by preventing their rapid degradation.
Humor releases adrenaline, endorphins and enkephalins, which are all natural pain killers and a natural reason to use humor, when inserting IVs.
Hans Kosterlitz and his colleague John Hughes are the first scientists to identify enkephalins, later called endorphins.
The 1960s saw the advent of Ronald Melzack and Patrick Wall's gate theory followed by the isolation of enkephalins and endorphins.