enkephalin

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Related to Enkephalins: encephalitis, Endorphins, somatostatin, substance P

enkephalin

(ĕnkĕf`əlĭn), one of several naturally occurring morphinelike substances (endorphinsendorphins
, neurotransmitters found in the brain that have pain-relieving properties similar to morphine. There are three major types of endorphins: beta endorpins, found primarily in the pituitary gland; and enkephalins and dynorphin, both distributed throughout the nervous
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) released from nerve endings of the central nervous system and the adrenal medulla. They act as analgesics and sedatives in the body and appear to affect mood and motivation.
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enkephalin

[en′kef·ə·lən]
(biochemistry)
A mixture of two polypeptides isolated from the brain; central mode of action is an inhibition of neurotransmitter release.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Biochemistry and Anatomical Distribution of Enkephalins and Their Receptors, DOPr and MOPr, in the CNS.
Racecadotril acts by inhibiting an enzyme intestinal enkephalinase, preventing breakdown of enkephalins. Increased levels of endogenous opioids (Enkephalins] in intestinal mucosa acting through delta receptors lead to increased absorption of luminal fluids.
The researchers also found that enkephalin, the natural drug-like chemical produced in that same brain region, surged when rats began to eat the candy-coated morsels, too.
Bernard Roques and Marie-Claude Fournie-Zaluski, inventors of the molecules and co-founders of Pharmaleads, explain that DENKI bring natural pain relief through inhibition of the two enzymes responsible for the rapid degradation of enkephalins, the main endogenous opioids, thus enhancing the effect of these potent physiological analgesics particularly in pain-affected areas.
[beta]-endorphin from pituitary gland and enkephalins from adrenal medulla).
Chronic blockade of D2 but not D1 dopamine receptors facilitates behavioural responses to endogenous enkephalins, protected by kelatorphan, administered in the accumbens in rats.
Effect of enkephalins on cardiac output and regional blood flow in conscious dogs.
Future antidepressants may involve neurotransmitters, other than 5-HT and NA, which could include dopaminergic pathways, opioid (antagonists of morphine-type drugs) receptors and the pentapeptides (enkephalins) which bind to these receptors.
Endogenously occurring opioids, the endorphins and enkephalins, are neuromodulators affecting pain perception and mood.
Research has demonstrated that acupuncture stimulates the body to release hormones, as well as naturally occurring opioid analgesics (termed endorphins and enkephalins) from the central nervous system.
Morphine and other opiates, including heroin which is synthesized from morphine, are chemically similar to the naturally produced compounds endorphins and enkephalins. The opiate molecules engage many nerve-receptor sites in the brain to mimic intense euphoria from high levels of endorphins.
Endogenous opioids: A group of small molecules, such as endorphins and enkephalins, that are naturally produced in the body and which have similar effects as the opiates (e.g., morphine and heroin); endogenous opioids modulate the actions of various neurotransmitters.