The spread of bla NDM-1, extensive and pan drug resistance, lack of new antimicrobials particularly in carbapenem resistant Enterobacteriaceae
(CRE) is an alarming clinical threat.
From October 2015 to January 2016, total 250 consecutive non-repetitive Enterobacteriaceae
isolates were tested for detecting their antimicrobial susceptibility pattern and production of ESBLs by a screening and confirmatory testing.
A total of 26 Enterobacteriaceae
isolates were isolated from different clinical cases and were diagnosed by using vitek -2 system , the number each isolates were (5) E.coli, (5) K.pneumoniae, (5) Salmonella typhi, (5) Shigella dysentery, (2) Serratia marcescens and (4) Proteus vulgaris.
Strategies for identification of carbapenemase-producing Enterobacteriaceae
. J Antimicrob Chemother.
Such non-carbapenemase- producing, carbapenem-resistant Enterobacteriaceae
(non-CP CRE) do not pose the same infection prevention and control risk.
Of 334 children, we found 67 (20.1%) from 32 preschools who had cefotaxim-resistant Enterobacteriaceae
isolates in their stool.
For example, some Enterobacteriaceae
isolates exhibit susceptibility to ertapenem, meropenem and imipenem but carry the blaKPC gene.
According to the Centers for Disease Control and Prevention (CDC), the emergence and dissemination of carbapenem resistance among Enterobacteriaceae
in the U.S.
Genes for AmpC b-lactamases are encoded on the chromosomes of several members of the family enterobacteriaceae
. Plasmid mediated AmpC b-lactamases are thought to have originated from chromosomes of several enterobacteriaceae
species and are infrequently inducible.4 Plasmids carrying genes for AmpC b-lactamases often carry multiple resistant genes, including genes for resistance to aminoglycosides, quinolones, chloramphenicol, sulfonamide, tetracycline, and trimethoprim as well as genes for other b-lactamases such as CTX-M-3.5 AmpC enzymes are located in periplasm, typically having molecular mass of 34 to 40 kDa and isoelectric points of >8.0.4 Plasmids with these genes can spread among members of the family Enterobacteriaceae
and have been documented in many countries.6
Beginning in January 2016, Verona integron-mediated metallo-[beta]-lactamase (VIM) producing carbapenem-resistant Enterobacteriaceae
(CRE) were identified in Indiana.
[1,2] There is an increase in the detection of Enterobacteriaceae
strains with resistance observed against betalactams, fluoroquinolones, aminoglycosides and polymyxins.