Enzyme Inhibitor


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Related to Enzyme Inhibitor: reversible inhibition, angiotensin converting enzyme inhibitor

Enzyme Inhibitor

 

a chemical substance that selectively inhibits the activity of an enzyme or a group of related enzymes. Even in very low concentrations, enzyme inhibitors repress an organism’s vital physiological functions. Many toxic substances, including pesticides, such nerve gases as lewisite, and such respiratory toxins as cyanides and hydrogen sulfide, have a toxic effect owing to the inhibition of enzymes, for example, the enzyme cholinesterase in arthropods.

The study of the effect of enzyme inhibitors on enzymes or groups of enzymes facilitates the search for antidotes or for new pesticides to control harmful insects, mites and ticks, and weeds. The term “enzyme inhibitors” sometimes refers to enzymes in the poisons of snakes, bees, and scorpions that destroy tissues or blood cells in man and animals.

References in periodicals archive ?
Angioedema incidence in US veterans initiating angiotensin-converting enzyme inhibitors.
Angiotensin I-converting enzyme inhibitor activity in fermented egg albumen
Effects of chronic angiotensin II receptor antagonist and angiotensin-converting enzyme inhibitor treatments on neurohormonal levels and haemodynamics during cardiopulmonary bypass.
Hsu, Bates, Kuperman & Curhan (2001), in their study, "Blood pressure and angiotensin converting enzyme inhibitor use in hypertensive patients with chronic renal insufficiency," sought to investigate actual clinical management of hypertension in 3,089 ambulatory patients with CKD by using medical record information from a Massachusetts hospital.
Shades of colour can be correlated to the amount of substrate or enzyme inhibitor present.
The covalently bound entity may also serve as an antagonist or agonist of a particular binding protein or as an enzyme inhibitor.
Temsirolimus is an enzyme inhibitor that blocks a specific T-cell function.
The UP-induced activation of ERK1/2 and p38 was attenuated by captopril, an angiotensin-converting enzyme inhibitor.
2% of residents with congestive heart failure were not receiving an angiotensin-converting enzyme inhibitor.
The immobilizing agent has a melting point of at least about 35[degrees]C and the enzyme inhibitor has an IC50 of about 50 mM or less, as measured by a General Fecal Enzyme Method.
The enzyme inhibitor can be used as a form of early intervention to delay the onset of life-threatening metabolic disorders.
Entacapone, a COMT enzyme inhibitor used in the treatment of Parkinson's disease, is Orion Pharma's patented molecule discovery, available globally as Comtess and Comtan.