Enzyme Preparation

Enzyme Preparation

 

an enzyme-containing drug that influences metabolism.

Enzyme preparations are obtained from plants, microorganisms and products of animal origin. Gastric juice, pepsin, and pancreatin are used to treat gastrointestinal diseases involving dysfunction of the digestive glands. Proteolytic enzyme preparations obtained from bovine pancreas, for example, chymotrypsin, are widely used in medical practice; they split the peptide bonds in proteins and peptides. When used locally, trypsin destroys necrotic tissue and fibrinous masses and liquefies viscous secretions, exudates, and blood clots. Intramuscular injections of trypsin have an anti-inflammatory effect. Trypsin preparations are inhaled or are injected intramuscularly to eliminate secretions and exudates in bronchitis and bronchiectasis and to treat thrombophlebitis, osteomyelitis, maxillary sinusitis, and iridocyclitis. Trypsin preparations are also applied locally to burns, decubitus ulcers, and purulent wounds.

The enzyme deoxyribonuclease liquefies pus and inhibits the development of herpesvirus and adenovirus; it is consequently used to treat herpetic and adenoviral eye infections, abscesses of the lungs, and lesions of the upper respiratory tract. Preparations containing the enzyme hyaluronidase increase tissue permeability and facilitate the flow of fluids in interstitial areas; they are used in the treatment of joint contractures, scars remaining after burns and surgery, and hematomas. Thromboembolism, thrombophlebitis, and myocardial infarction are treated with fibrinolysin, which dissolves newly formed thrombi. Penicillinase obtained from a Bacillus cereus culture inactivates penicillin drugs and is used to control allergic reactions caused by these drugs.

Enzyme inhibitors are also used in medical practice. These include anticholinesterase agents that inhibit cholinesterase, and certain antidepressants that inhibit monoamine oxidase. Carbonic anhydrase inhibitors such as Diacarb are used as diuretics, and such inhibitors of proteolytic enzymes as Trasylol are used to treat acute pancreatitis.

REFERENCES

Kaplanskii, S. Ia. “Primenenie fermentnykh preparatov v terapii razlichnykh zabolevanii.” In Aktual’nye voprosy sovremennoi biokhimii, vol. 2. Moscow, 1962.
Mashkovskii, M. D. Lekarstvennye sredstva, 7th ed., part 2. Moscow, 1972.

V. V. CHURIUKANOV

References in periodicals archive ?
5, 2015 /PRNewswire/ -- In recent years, the global industrial enzyme preparation market size increased year by year, registering a CAGR of 5%, approximating USD4.
Stimulated by the growing demand for enzyme preparations and favorable policies, China's industrial enzyme preparation output reached 1.
Indeed, the additive effect of multiple enzyme preparation with phytase, carbohydrases and proteases has been reported in broiler chickens when fed onto the nutritionally deficient diet.
Compared to papain, Promod[TM] 950L is an enzyme preparation with broad substrate specificity.
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Protein estimation: The protein content of the enzyme preparation was estimated by Lowry method using Bovine serum albumin as standard (Lowry et al.
The main aim of this work is to analyse the effect of chlorides on biochemical oxidation process and activated sludge community growth, to investigate the influence of the enzyme preparation upon water quality.
The efficiency of purification at different steps was characterized as PSAO specific activity per 1 mg enzyme preparation and the percentage of the recovery of total PSAO activity.
It is an alpha-galactosidase-A enzyme preparation produced from human cell
A 20 [micro]l volume (containing 8-12 [micro]g of protein) of the enzyme preparation was added to the reaction mixture and pre-incubated for 10 min at 37[degrees]C.
Enhanze SC is a formulation of recombinant human hyaluronidase manufactured by a biotechnology process that results in a highly purified enzyme preparation.
This case is distinctive because of the adult presentation, and because the patient's symptoms developed long after he had discontinued taking a high-strength enzyme preparation.

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