Enzyme Inhibitor

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Enzyme Inhibitor

 

a chemical substance that selectively inhibits the activity of an enzyme or a group of related enzymes. Even in very low concentrations, enzyme inhibitors repress an organism’s vital physiological functions. Many toxic substances, including pesticides, such nerve gases as lewisite, and such respiratory toxins as cyanides and hydrogen sulfide, have a toxic effect owing to the inhibition of enzymes, for example, the enzyme cholinesterase in arthropods.

The study of the effect of enzyme inhibitors on enzymes or groups of enzymes facilitates the search for antidotes or for new pesticides to control harmful insects, mites and ticks, and weeds. The term “enzyme inhibitors” sometimes refers to enzymes in the poisons of snakes, bees, and scorpions that destroy tissues or blood cells in man and animals.

References in periodicals archive ?
We aimed to identify how often AE is associated with angiotensin-converting enzyme inhibitor (ACEI-AE) therapy and whether the severity of AE episodes in these patients differs from the severity of idiopathic AE.
An evaluation of risk factors foe adverse drug events associated with angiotensin-converting enzyme inhibitors.
Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema.
Correction page 245-250/Duzeltme sayfa 245-250: The effects of chronic usage of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on contrast-induced nephropathy in low-risk patients Nezihi Baris, Ebru Ozpelit, Nazile Bilgin Dogan, Hande Kangul, Sefa Gul, Bahri Akdeniz, Sema Guneri
We will unlock new 3-D information for glycocerebrosidase 2 (GBA2) and use these together with GBA1 to design and exploit novel and specific enzyme inhibitors as mechanistic and cellular probes, novel chaperones and imaging agents.
One group received calcium channel blockers (CCBs), and the other group received angiotensin converting enzyme inhibitors (ACEIs) daily for duration of 6 months from the day of enrolment during the one year study period.
An evaluation of risk factors for adverse drug events associated with angiotensin-converting enzyme inhibitors.
The researchers studied eight treatment classes, including angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, [beta]-blockers, calcium channel blockers, loop diuretics, selective serotonin reuptake inhibitors, statins, and thiazide diuretics.
Are angiotensin-converting enzyme inhibitors effective in decreasing mortality and morbidity in patients with heart disease but without heart failure or systolic dysfunction?
Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists.
Previous use of erythromycin in patients taking the enzyme inhibitors was also checked, and was not a problem.
3) In addition, NSAIDs aggravate heart failure by inducing water retention and by blunting the effects of diuretics, [beta]-blockers, and angiotensin-converting enzyme inhibitors.