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Inflammation of the esophagus.



inflammation of the mucosa of the esophagus. Esophagitis may be an independent disease or, more often, a symptom of another disease of the esophagus, stomach, or other organ. The inflammation is frequently caused by chemical, mechanical, or thermal irritation of the esophagus; for example, it may be caused by eating very hot and spicy food.

Catarrhal, phlegmonous, necrotic, and other forms of esophagitis are distinguished based on the severity of the inflammatory changes. In severe cases the inflammatory process may extend to the muscular layer of the esophagus, and sometimes, to the surrounding mediastinal tissue, giving rise to mediastinitis. One form of the disease, peptic esophagitis, is caused mostly by a reflux of the acidic contents of the stomach into the esophageal lumen in cases of hiatus hernia. Peptic esophagitis is sometimes associated with the development of an ulcer in the esophageal wall.

The course of the disease may be acute or chronic. Chronic esophagitis is frequently caused by alcohol abuse or smoking. The symptoms include a burning sensation, retrosternal pain on swallowing, excessive salivation, and regurgitation of food. Esophagoscopy is sometimes used to diagnose the disease. Treatment is by diet (eliminating coarse, hot, and acidic foods), pain relievers, astringent and antispasmodic drugs, and, in some forms, antibiotics and surgery.


Vasilenko, V. Kh., A. L. Grebnev, and M. M. Sal’man. Bolezni pishchevoda. Moscow, 1971.


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The small-caliber esophagus: Radiographic sign of idiopathic eosinophilic esophagitis.
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Clinical and endoscopics features of eosinophilic esophagitis in adults.
4,5) However, the pathologic features intrinsic in eosinophilic esophagitis do not respond to acid-suppression treatment.
A review of the Eosinophilic Esophagitis products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
Baseline endoscopic scores assessing strictures, fissures, rings, and other abnormalities were in the moderate range on a 0-13 severity scale, so the finding of a lack of benefit for dilation as part of initial treatment in eosinophilic esophagitis may not extend to the minority of patients having truly severe stricturing disease, Dr.
The etiology of eosinophilic esophagitis is unclear, but it appears that it is the result of an eosinophil-associated inflammation of epithelia, similar to that seen in bronchial asthma and atopic dermatitis.
We are also excited about the progress we are making with RPC4046 in eosinophilic esophagitis and our pre-clinical oral GLP-1 program.
The incidence of eosinophilic esophagitis and other severe food allergies among children is increasing.
The esophagram was consistent with eosinophilic esophagitis (EoE) and also suggested a Schatzki's ring.
Reflux and eosinophilic esophagitis are clearly 2 different entities that do not respond to the same treatment modalities.
Food allergy-related conditions such as food protein-induced enterocolitis syndrome (FPIES), eosinophilic esophagitis (EE), Oral Allergy Syndrome (OAS), and atopic dermatitis are also addressed in the guidelines.

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