Esophagitis

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Related to Eosinophilic esophagitis: Eosinophilic gastroenteritis

esophagitis

[ə‚säf·ə′jīd·əs]
(medicine)
Inflammation of the esophagus.

Esophagitis

 

inflammation of the mucosa of the esophagus. Esophagitis may be an independent disease or, more often, a symptom of another disease of the esophagus, stomach, or other organ. The inflammation is frequently caused by chemical, mechanical, or thermal irritation of the esophagus; for example, it may be caused by eating very hot and spicy food.

Catarrhal, phlegmonous, necrotic, and other forms of esophagitis are distinguished based on the severity of the inflammatory changes. In severe cases the inflammatory process may extend to the muscular layer of the esophagus, and sometimes, to the surrounding mediastinal tissue, giving rise to mediastinitis. One form of the disease, peptic esophagitis, is caused mostly by a reflux of the acidic contents of the stomach into the esophageal lumen in cases of hiatus hernia. Peptic esophagitis is sometimes associated with the development of an ulcer in the esophageal wall.

The course of the disease may be acute or chronic. Chronic esophagitis is frequently caused by alcohol abuse or smoking. The symptoms include a burning sensation, retrosternal pain on swallowing, excessive salivation, and regurgitation of food. Esophagoscopy is sometimes used to diagnose the disease. Treatment is by diet (eliminating coarse, hot, and acidic foods), pain relievers, astringent and antispasmodic drugs, and, in some forms, antibiotics and surgery.

REFERENCE

Vasilenko, V. Kh., A. L. Grebnev, and M. M. Sal’man. Bolezni pishchevoda. Moscow, 1971.

I. V. IAREMA

References in periodicals archive ?
Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis.
Data source: A retrospective study of data on 1,025 children seen at one institution for eosinophilic esophagitis.
Markers of antigen presentation and activation on eosinophils and T cells in the esophageal tissue of patients with eosinophilic esophagitis.
Wang FY, Gupta SK, Fitzgerald JE Is there a seasonal variation in the incidence or intensity of allergic eosinophilic esophagitis in newly diagnosed children?
Conclusion: Eosinophilic esophagitis should be considered as active diagnosis in presence of suggestive symptoms.
Recent studies exploring elemental diets in children have found that these diets can lead to a complete amelioration of esophageal eosinophils, confirming that food allergies are related to eosinophilic esophagitis in at least some patients.
Eosinophilic Esophagitis (EE) is an allergic inflammatory reaction of the oesophagus, the muscular tube that carries food from the throat to the stomach.
Global Markets Direct's, 'Eosinophilic Esophagitis - Pipeline Review, H2 2012', provides an overview of the Eosinophilic Esophagitis therapeutic pipeline.
Capucilli, MD (Fellow-in-Training), Children's Hospital of Philadelphia, for his abstract entitled "A Comparison of Comorbid Diagnoses in Children with and without Eosinophilic Esophagitis in a Large Primary Care Population," and Ichiro Nomura, MD (Member), National Research Institute for Child Health and Development, for his abstract entitled "Elevated Serum TSLP, IL-33, 6Ckine and MCP-3 Levels in School Children or Older Patients with Eosinophilic Gastroenteritis.
A pivotal Phase 3 study is planned for 2018 evaluating the use of dupilumab in eosinophilic esophagitis (EoE), a condition for which there are no approved therapies in the U.
Eosinophilic esophagitis is an inflammatory disorder of the esophagus, which decreases the ability of the esophagus to stretch and accommodate swallowed foods, presenting with mainly dysphagia and food stuck in the esophagus and other less common symptoms including heartburn and chest pain.

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