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(ĕp'ənĕf`rīn), hormonehormone,
secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue.
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 important to the body's metabolism, also known as adrenaline. Epinephrine, a catecholaminecatecholamine
, any of several compounds occurring naturally in the body that serve as hormones or as neurotransmitters in the sympathetic nervous system. The catecholamines include such compounds as epinephrine, or adrenaline, norepinephrine, and dopamine.
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, together with norepinephrinenorepinephrine
, a neurotransmitter in the catecholamine family that mediates chemical communication in the sympathetic nervous system, a branch of the autonomic nervous system.
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, is secreted principally by the medulla of the adrenal glandadrenal gland
or suprarenal gland
, endocrine gland (see endocrine system) about 2 in. (5.1 cm) long situated atop each kidney. The outer yellowish layer (cortex) of the adrenal gland secretes about 30 steroid hormones, the most important of which are aldosterone and
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. Heightened secretion caused perhaps by fear or anger, will result in increased heart rate and the hydrolysis of glycogen to glucose. This reaction, often called the "fight or flight" response, prepares the body for strenuous activity. The hormone was first extracted (1901) from the adrenal glands of animals by Jokichi Takamine; it was synthesized (1904) by Friedrich Stolz. Epinephrine is used medicinally as a stimulant in cardiac arrest, as a vasoconstrictor in shock, as a bronchodilator and antispasmodic in bronchial asthma, and to lower intra-ocular pressure in the treatment of glaucoma.


See B. B. Hoffman, Adrenaline (2013).

The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved. www.cc.columbia.edu/cu/cup/


A hormone which is the predominant secretion from the adrenal medulla; also known as adrenalin, it has the structure shown. Epinephrine is a sympathomimetic substance; that is, it acts on tissue supplied by sympathetic nerves, and generally the effects of its action are the same as those of other nerve stimuli. Conversely, the stimulation of the splanchnic or visceral nerves will cause the rapid release of the hormone from the medullary cells of the adrenal gland. Thus, epinephrine plays an important role in preparing the organism to meet conditions of physiologic emergency.

When injected intravenously, epinephrine causes an immediate and pronounced elevation in blood pressure, which is due to the coincident stimulation of the action of the heart and the constriction of peripheral blood vessels. The chief metabolic changes following the injection of epinephrine are a rise in the basal metabolic rate and an increase of blood sugar. These effects of epinephrine are transitory. See Adrenal gland, Carbohydrate metabolism

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McGraw-Hill Concise Encyclopedia of Bioscience. © 2002 by The McGraw-Hill Companies, Inc.


C9H13O3N A hormone secreted by the adrenal medulla that acts to increase blood pressure due to stimulation of heart action and constriction of peripheral blood vessels. Also known as adrenaline.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The EpiPen shortage can be traced at least in part to two factories in Missouri.
Mylan, which had a market value of $9.5 billion prior to Monday's announcement, last year said it would review its business as it grapples with lower prices of generic drugs and declining sales of its EpiPen emergency allergy treatment.
What's important to remember is an EpiPen might not contain the right dose to prevent serious anaphylaxis and t's therefore never worse taking the risk.
Coroner Mary Hassell called for more awareness of EpiPens as she recorded he died from an "extraordinarily rare" reaction.
Staff who treated him at the school when he went into anaphylactic shock said that they would not have given him an epipen that belonged to another student for fear of a "domino effect".
The Epipen injection is an auto-injector device, issued to people who suffer from severe allergies as a precautionary tool, which is recommended to be carried with them at all times in case of a reaction.
PEOPLE with severe allergies could be put at increased risk of harm due to a critical shortage of EpiPens across Wales, it is claimed.
She said: "While the availability of Epipen products is currently limited, alternative adrenaline auto-injectors continue to be available."
EpiPens are the most common adrenaline autoinjector devices and are issued to people who suffer from serious allergies.
Last week, an inquest heard that Natasha Ednan-Laprose, 15, died on a flight after suffering an allergic reaction to a baguette containing sesame seeds, despite her father injecting her with two EpiPens.
The FDA has previously approved other epinephrine autoinjectors, which include brand-name products and so-called "authorized generic" versions of EpiPen and Adrenaclick.