epigenetics

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Related to Epigenetic regulation: Epigenetics, DNA methylation

epigenetics

[¦ep·ə·jə¦ned·iks]
(genetics)
The study of those processes by which genetic information ultimately results in distinctive physical and behavioral characteristics.
References in periodicals archive ?
Genome-wide profiling of DNA methylation provides insights into epigenetic regulation of fungal development in a plant pathogenic fungus, Magnaporthe oryzae.
Epigenetic regulation involves the addition of small molecules to the DNA or to the histones associated with DNA.
miRNA does not alter the genetic code but rather affects its expression, providing another mechanism for epigenetic regulation.
In this study, we identified the IGENs in normal bladder cells and bladder cancer cells and then investigated the impact of epigenetic regulation and miRNA regulation on bladder carcinogenesis by comparing the IGEN in normal bladder cells with that in bladder cancer cells.
In addition, the authors examine evidence of epigenetic regulation of A[beta] plaque formation in AD neurons and discuss different potential therapeutic approaches.
sup][14] This result supports existing findings of epigenetic regulation of TL.
DNA hypermethylation of this CDKN2A-specific region correlated with a significant increase in p14(ARF) and p16(INK4A) expression in HPV-positive OPSCC primary tumors, suggesting a potential mechanism connecting HPV positivity and expression of CDKN2A transcripts that is separate from tumor suppressor proteins p53 and pRb, and may involve direct epigenetic regulation.
Epigenetic regulation constitutes an important mechanism by which dietary components can selectively activate or inactivate gene expression (Meeran et al.
EpiTherapeutics has generated a library of first-in-class, selective small molecule inhibitors of epigenetic regulation of gene transcription, in particular histone demethylases.
One of the main benefits of epigenetic regulation discoveries is that epigenetic changes are reversible and that they can be chemically controlled by drugs.
Two major components of epigenetic regulation are DNA methylation and histone acetylation.