Epimerase


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epimerase

[ə′pim·ə‚rās]
(biochemistry)
A type of enzyme that catalyzes the rearrangement of hydroxyl groups on a substrate.

Epimerase

 

any enzyme of the isomerase class that catalyzes the inversion of L- and D-isomers with several centers of asymmetry. For example, aldose 1-epimerase (a mutarotase) catalyzes the conversion of of α-D-glucose into β-D-glucose. Epimerases are widely found in nature. (SeeRACEMASE.)

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The conversion of MI to DCI is achieved by an epimerase enzyme and its activity was observed to correlate inversely with the degree of insulin resistance.
Those with the most promising results include inhibitors of UDP2 epimerase, Methionine tRNA synthase, the FtsZ proteins, and NDM-1 beta lactamase.
People with galactosemia, either classic galactosemia or epimerase deficiency galactosemia, have genetic mutations that decrease their levels of the key enzymes (GALT and GALE) responsible for the metabolism of a common form of dietary sugar.
Target genes for detecting GIT microbiota's role metagenome in chicken metabolism Name Metabolism Function (protein) Glucoside hydrolase Carbohydrate Hydrolysis of carbohydrate Polysaccharide lyase Carbohydrate esterase Galactose transport protein Glucosamine-6-phosphate deaminase Methylmalonyl decarboxylase Fatty acids Propionate production Butyryl-CoA:acetate-CoA Butyrate production transferase 3-hydroxybutyryl-CoA Butyrate fermentation dehydrolase Acetate kinase Acetate fermentation Phosphate acetyltransferase Acetate fermentation Methylmalonyl-CoA epimerase Propionate production Dipeptidyl aminopeptidase Nitrogen Protein hydrolysis GIT, gastrointestinal tract.
du Pont de Nemours and Company (Wilmington, DE) has patented an isolated nucleic acid fragment encoding a plant enzyme that catalyze steps in the biosynthesis of lysine, threonine, methionine, cysteine and isoleucine from aspartate, the enzyme a member selected from the group consisting of: dihydrodipicolinate reductase, diaminopimelate epimerase, threonine synthase, threonine deaminase and S-adenosylmethionine synthetase.