epigenetics

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epigenetics

[¦ep·ə·jə¦ned·iks]
(genetics)
The study of those processes by which genetic information ultimately results in distinctive physical and behavioral characteristics.
References in periodicals archive ?
The GNAS complex locus and human diseases associated with loss-of-function mutations or epimutations within this imprinted gene.
Also, the epigenetics consolidated a formal theory of carcinogenesis [6] that could explain cancer predisposition in humans related to epimutations (an epigenetic hereditary abnormality in gene expression) transmitted from mother to child [7].
AdG: Our current work is focused on epimutations; we feel that the work of experts in the field of the genetics of aging (Jan Vijg's group at the Albert Einstein College of Medicine in particular) has already shown really conclusively that mutations accumulate far too slowly in most tissues (notably the brain) during adulthood to have any chance of contributing to age-related ill-health.
It serves to erase random changes in epigenetic marks (i.e., epimutations) that have occurred in the germ cells (i.e., gametes) and to restore the ability of the fertilized egg cell (i.e., zygote) to develop into all the different cell types and tissues (Reik et al.
The application of these tools will provide strong evidences for the relationship between epimutations and diseases.
Methylation sequencing analysis refines the region of H19 epimutation in Wilms tumor.
Cancer is the most widely studied disease known to be associated with epimutations, where a part or parts of the epigenome don't properly function.
In contrast to LS, in which a monoallelic mutation of one of the MMR genes is inherited in the germline, sporadic MSI is associated with acquired epimutation of both copies of MLH1.
Allelespecific germ cell epimutation in the spacer promoter of the 45S ribosomal RNA gene after Cr(III) exposure.
The lab is trying to understand how problems encountered as cells replicate their DNA lead to mutations and to epigenetic alterations which cause changes in the pattern of gene expression in cells, sometimes known as epimutations. Both mutations and epimutations are seen extensively in cancer cells and drive the development of the disease, so understanding their origin is central to understanding how cancer arises.
Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations. PLoS One 8(1):e55387, PMID: 23359474, https://doi.org/10.1371/journal.pone.0055387.
Weidner et al., "Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia," Leukemia, vol.