The value of epithelial membrane antigen
expression in separating benign mesothelial proliferation from malignant mesothelioma: a comparative study.
Epithelial membrane antigen
may also be expressed by the tumor cells, but to a lesser extent (Figure 7).
These malignancies do not stain for epithelial membrane antigen
All cases were negative for epithelial membrane antigen
(9 of 9) (11,12,14,16) and placental alkaline phosphatase (4 of 4 cases).
High-level expression of CD23, low-level expression of pan-leukocyte antigen and S-100 protein, and focal expression of epithelial membrane antigen
were observed, as well.
2), cytokeratin 7 and 20, epithelial membrane antigen
, a-smooth muscle actin, muscle actin, desmin, myoglobin, CD34, CD10, chromogranin A, synaptophysin, and CD117.
Immuno staining was negative for estrogen and progesterone receptors and positive for epithelial membrane antigen
They are negative for S100 protein (Figure 4), desmin, CD117 (c-Kit; Figure 5), epithelial membrane antigen
(EMA), CD31, bcl-2, cytokeratin AE1/3, PGM1, COX-2, h-caldesmon, cyclin D1, CD21, CD23, CD35, and factor XIIIa.
2, S-100 protein, glial fibrillary acidic protein, immunoreactive calcitonin, immunoreactive parathyroid hormone, and epithelial membrane antigen
Some tumors are reported to be positive for cytokeratin 20, epithelial membrane antigen
(Figure 3, B), S100, carcinoembryonic antigen (CEA), CA 19.
The table states that atypical teratoid/rhabdoid tumor is negative for epithelial membrane antigen
(EMA); however, this is incorrect in that most of these tumors stain with EMA.
4) Epithelioid sarcoma is a mesenchymal tumor with a predominant epithelial differentiation, showing reactivity for both epithelial and mesenchymal markers, such as cytokeratin, epithelial membrane antigen
, vimentin and CD34.