epitope

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epitope:

see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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epitope

[′ep·ə‚tōp]
(immunology)
The portion of the antigen molecule that determines its capacity to combine with the specific combining site of its corresponding antibody in an antigen-antibody interaction.
References in periodicals archive ?
The immune-dominant epitopes were identified within the bovine RVA VP6 protein by Protean software implemented in DNA STAR using various predictive algorithms.
The computer-generated binding sequences were then made into synthetic epitopes for testing purposes.
HLA selection and epitope prediction of A(H1N1)pdm09 surface glycoproteins Epitopes were predicted against selected alleles of 10 MHC I Supertypes (A2, A3, B7, B15, A24, B44, B57, ABX, B27 and BX) and 8 MHC II alleles of Supertype DRB1 that covers 99% Asian population (De Groot et al.
24-26) Biopanning combines current protein and peptide expression and modification methods with simple microbiological procedures that enable fast amplification of hundreds of selected peptides, which can be applied to retrieve collections of relevant epitopes and mimotopes binding to antibodies of interest.
The T cells were then grown in the lab and exposed to various peptides, including the suspect epitopes, to identify and confirm that only one triggered the greatest chemical response from the cultured T cells.
We hypothesize that older people are somewhat protected because the epitopes present in flu strains before 1957 may be similar to those found in the current H1N1 strain, or at least similar enough that the immune system of the previously infected person recognizes the pathogen and knows to attack.
Results obtained from the present study can be summarized as follows; 1-Shared epitopes were detected in half of the RA patients and the most frequent HLA-DRB1 subtype synthesizing shared epitope in these patients was HLA-DR4 gene, followed by HLA-DR1 gene.
For MHC class II antigen-restricted epitopes essential for antibody and Th1 responses, HA of pandemic (H1N1) 2009 virus contains HLA-DRA*0101/DRB1 *0101-restricted SVIEKMNTQFTAV (5), as well as HLA-DRA*0101/ DRB1*0401-restricted EKMNTQFTAVGKE, TGLRNIPSIQSRG, and ELLVLLENERTLDY (5), and HLADRB5* 0101-restricted DYEELREQL SSVSSFERFE (5) epitopes.
JPT offers four delivery options for T-cell assays: 1) Fast Track for proteome-wide T-cell epitope discovery programs 2) Research Track for T-cell epitope mapping studies 3) Discovery Track for immune monitoring applications and 4) Trial Track for vaccination trials.
Rather, the autoimmune response spreads to a number of different second epitopes in these individuals, thereby exhibiting more variation than the response in patients with the early anti-Sm autoantibody response.
The Ii-Key motif from the Ii protein acts at an allosteric site adjacent to the MHC class II antigenic peptide-binding trough to enhance presentation of covalently linked epitopes 200-500 times in vitro.