epitope

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Related to Epitopes: apoptosis, antigenic determinant, Paratope, Haptens

epitope:

see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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epitope

[′ep·ə‚tōp]
(immunology)
The portion of the antigen molecule that determines its capacity to combine with the specific combining site of its corresponding antibody in an antigen-antibody interaction.
References in periodicals archive ?
In general, monoclonal antibody analysis will result in one epitope, whereas polyclonal antibody analysis may result in numerous epitopes.
MAbs 920, 441, 625 (for the epitopes comprising amino acid residues 135-145, 148-158, and 169-178, respectively) were used as the control antibodies.
EP-1090 encodes 21 CTL epitopes from conserved regions of multiple HIV virus proteins.
Identification of neutralizing and nonneutralizing epitopes in the porcine reproductive and respiratory syndrome virus GP5 ectodomain.
These results demonstrate that protein structure plays an important role in the stability of this allergen to resist digestion and provide a link between food allergen structure, stability to digestion, and the immunodominant IgE-binding epitopes within a population of food-allergic individuals.
The question is whether such an expression library immunization (ELI) vaccine could deliver multivalent epitopes to drive immune responses to HIV.
Ninety-one percent of patients treated with EP-2101, who were tested for immune response, had a measurable response to at least one of the epitopes included in the vaccine with 64% responding to at least three of the epitopes.
Samples from the rest of the patients, however, either reacted with the epitopes in a broadly heterogeneous pattern (n = 8) or did not recognize any of the epitopes in our panel of Tg-Mabs (n = 13; Fig.
The EP-2101 cancer vaccine candidate used in these trials includes nine CTL epitopes from four tumor associated antigens (TAA) including two proprietary native epitopes and seven modified, or analog, epitopes.
announced its anticipated launch of Phase I human clinical trials with a therapeutic hepatitis B vaccine incorporating our epitope technology.
T-cell epitopes were identified, and transgenic mice with the HLA-DQ locus exhibited strong T-cell responses to short ragweed extracts.
This problem may be circumvented by using polyclonal antibody preparations or MAb cocktails that bind multiple epitopes in the targeted antigen.