Markovitz's was that vaccination with DerG LEAPS conjugates of distinct PG epitopes
alone or together were effective at modulating the inflammatory response and arresting the progression of arthritis.
Six promising peptides (R6), namely, Rv1986-P9, Rv1986-P15, Rv1986-P16, Rv1988-P4, Rv1988-P11, and Rv1983-P4 (all identified by epitopes
screening) were pooled together to assess the TB diagnosis potential in patients with symptoms of tuberculosis.
However, the major B and T cell antigen epitopes
of Der f 33 have not been reported.
Synthetic peptides corresponding to the protective B- and Tcell epitopes
can be considered good candidates for FMD vaccines as, among other advantages, they are safe and support a rational design and their production and characterization are simple.
For prediction of the linear B-cell epitopes
in the ACTTS protein primary amino acids sequence, BCPREDS server was used.
At this point, epitopes
masked by IL-7/IL-7R[alpha] are reexposed in free [gamma]c and are detected with relevant mAbs.
Identification of T-Cell Epitopes
. Protegen (http://www .violinet.org/protegen/) , an antigen database and analysis system, was used to assess the antigenicity of Ag85B.
We have turned the problem on its head and only use previously-tested epitopes
. This allows us to get the best of both worlds, designing a vaccine with a very high likelihood of success."
Immunohistochemistry as a procedure is affected by preanalytic variables, such as tissue fixation, embedding the tissue in paraffin, and performance of epitope
retrieval, as parts of the actual IHC procedure.
It is also known that a substantial percentage of circulating BNP and NT-proBNP detected in those with advanced HF is actually an uncleaved precursor peptide, proBNP whose detection occurs owing to cross-reactivity between epitopes
in BNP and NT-proBNP.
It is encouraging to see that this kit may have a potential role in future clinical management of CRPC patients, leading to better monitoring and possibly improved survival rates," said Ping Gao, President of Epitope
Protein sequence was analyzed for the prediction of B-cell epitopes
by ABCpred server using neural network (Saha et al., 2006).