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A hormone, thought to be produced by the kidneys, that regulates erythropoiesis, at least in higher vertebrates.



a hormone that stimulates the formation of erythrocytes in bone marrow. Characterized as a glycoprotein, erythropoietin has a carbohydrate content of 35 percent. It has a molecular weight of 30,000–40,000 and possesses antigenic properties. Erythropoietin is inactivated by neuraminidase, trypsin, chymotrypsin, and papain.

Erythropoietin was discovered by the French researchers F. Corneau and C. de Flandre in 1906 in rabbit serum that they tested after drawing blood. The hormone is found in low concentrations under normal physiological conditions, but the levels increase when the subject is in a state of hypoxia as a result of the loss of blood, a decrease in the oxygen content of the air, or various forms of anemia. Most scientists believe that erythropoietin is formed in the kidneys. When the hormone acts on stem cells in bone marrow, it causes their differentiation into cells of the erythroid series.


Fedorov, N. A., and M. G. Kakhetelidze. Eritropoetin. Moscow, 1973.
Normal’noe krovetvorenie i ego reguliatsiia. Moscow, 1976.
Gordon, A. S. Regulation of Hematopoiesis, vol. 1. New York [1970].


References in periodicals archive ?
In our study we compared the efficacy of twice-weekly IV Eprex with thrice-weekly IV Eprex in our dialysis population by evaluating haemoglobin levels in these patients and determining the cost benefits of placing patients on a reduced frequency regimen.
The company is also planning a study of progression-free survival and other outcomes, including overall survival and thrombotic events, in anemic women who are receiving first-line chemotherapy for metastatic breast cancer; they will be randomized to receive Eprex or placebo, with a target hemoglobin of 12 g/dL.
Aranesp [R] and Eprex [R] should not be increased by more than 30% increments at any given time, whereas dose decreases may be more than 30% increments
J&J reported the week prior that early data showed Eprex patients in the German study died more frequently than placebo patients, and said it was doing additional analyses to better understand the findings.
The apparent link between Eprex and pure red cell aplasia (PRCA) was first made by a team of French physicians last February.
1) Johnson & Johnson made several, what it considered minor, manufacturing changes in Eprex production.
The increased incidence of pure red cell aplasia with an Eprex formulation in uncoated rubber stopper syringes.
Its sales of Procrit and a similar drug, Eprex, dropped 14% worldwide in the second quarter to $652 million, and fell 23% in the United States to $346 million.
Novartis AG's Sandoz unit, the world's second-largest maker of generic drugs, became the first company to win approval for a biological copy of Johnson & Johnson's (New Brunswick NJ) Eprex anemia treatment, allowing it to offer cheaper versions to Europeans.
The FDA considers Eprex and NeoRecormon to be in the same class as the three erythropoietin products approved in the United States: erythropoietin alfa (Epogen) and darbepoetin alfa (Aranesp), both by" Amgen: and Procrit, by Ortho Biotech Products.
Eprex and Procrit, both marketed by Johnson & Johnson, also treat anemia.