Epstein-Barr virus

(redirected from Epstein Barr)
Also found in: Dictionary, Thesaurus, Medical.
Related to Epstein Barr: mononucleosis

Epstein-Barr virus

(EBV), herpesvirus that is the major cause of infectious mononucleosismononucleosis, infectious
, acute infectious disease of older children and young adults, occurring sporadically or in epidemic form, also known as mono, glandular fever, and kissing disease. The causative organism is a herpesvirus known as Epstein-Barr virus.
..... Click the link for more information.
 and is associated with a number of cancers, particularly lymphomaslymphoma, non-Hodgkin's,
any cancer of the lymphoid tissue (see lymphatic system) in which the Reed-Sternberg cells characteristic of Hodgkin's disease (the other category of lymphoma) are not present.
..... Click the link for more information.
 in immunosuppressed persons, including persons with AIDS. Epstein-Barr is a ubiquitous virus, so common that it has been difficult to determine whether it is the cause of certain diseases or whether it is simply there as an artifact. In Third World nations, most children are infected with EBV; in most industrialized nations, about 50% of the people are infected. Research has found that all of the lymphomas associated with AIDS and most lymphomas in other immunocompromised persons are connected with latent EBV infection. EBV has been found in biopsy tissue of patients with Hodgkin's diseaseHodgkin's disease,
a type of cancer of the lymphatic system. First identified in 1832 in England by Thomas Hodgkin, it is a type of malignant lymphoma. Incidence peaks in young adults and the elderly.
..... Click the link for more information.
, breast cancer, and some smooth muscle tumors. EBV also was formerly suspected as the cause of chronic fatigue syndromechronic fatigue syndrome
(CFS), collection of persistent, debilitating symptoms, the most notable of which is severe, lasting fatigue. In other countries it is known variously as myalgic encephalomyelitis (ME), chronic fatigue and immune dysfunction syndrome, and postviral
..... Click the link for more information.
 (originally named chronic EBV syndrome).

Epstein-Barr virus

An antigenically distinct member of the herpesvirus group of viruses, whose genome is DNA. EB virus is the cause of one benign disease (infectious mononucleosis), and is associated with certain types of cancer; however, the great majority of EB virus infections are clinically inapparent. The virus was detected initially by electron microscopy in a small proportion of cells in continuous lymphoblastoid cell lines derived from Burkitt's lymphoma (but particles have not been seen in cells of the tumor itself). The virus also has been detected in cell lines derived from nasopharyngeal carcinomas, a type of cancer found with high frequency in persons from southern China. The virus is found in peripheral blood leukocytes from normal individuals and from patients with infectious mononucleosis. See Infectious mononucleosis, Lymphoma

If EB virus is indeed confirmed as having a role in the development of human malignancies, then one major question to be resolved is how a virus so ubiquitous can be involved in so wide a variety of responses. However, it should be recalled that many virus infections (for example, polio virus, hepatitis viruses, certain of the arboviral encephalitides) have a wide spectrum of outcomes, ranging from inapparent infection to severe syndromes. See Animal virus

Epstein-Barr virus

[¦ep·stīn ¦bär ‚vī·rəs]
(virology)
Herpeslike virus particles first identified in cultures of cells from Burkett's malignant lymphoma.
References in periodicals archive ?
Immunohistochemical Expression of Epstein Barr Virus Antigen Latent Membrane Protein-1 and Bcl-2 in Classical Hodgkin Lymphoma.
Lopategui JR, Gaffey MJ, Frierson H Detection of Epstein Barr viral RNA in sinonasal undifferentiated carcinoma from Western and Asian patients: Am J Surg Pathol 18:391- 398, 1994.
Use of quantitative competitive PCR to measure Epstein Barr virus genome load in the peripheral blood of paediatric transplant patients with lymphoproliferative disorders.
The cellular protein PRA1 modulates the anti-apoptotic activity of Epstein Barr virus BHRF1, a homologue of Bcl-2, trough direct Interaction.
Anahtar sozcukler: Asimetrik tonsil, Epstein Barr virus, tekrarlayan tonsillit, tonsiller hipertrofi
Hepatic function in mononucleosis induced by Epstein Barr virus and cytomegalovirus.
Birmingham University's team will examine the role the Epstein Barr virus (EBV) plays in the development of Hodgkin's lymphoma and nasopharyngeal carcinoma - cancer of the upper respiratory system.
Key Words: Epstein Barr virus, EBV, hepatitis, liver dysfunction
Determinacion de anticuerpos IgM contra el antigeno de capside del virus de Epstein Barr
Induction of bcl-2 expression by Epstein Barr virus latent membrane protein 1 protects infected B cells from programming cell death.
The company's Epstein Barr virus vaccine is designed to protect organ transplant patients against this virus, which can potentially cause malignant lymphoma.