Epstein-Barr virus


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Related to Epstein-Barr virus: Guillain-Barre syndrome, cytomegalovirus, mononucleosis, Lupus

Epstein-Barr virus

(EBV), herpesvirus that is the major cause of infectious mononucleosismononucleosis, infectious
, acute infectious disease of older children and young adults, occurring sporadically or in epidemic form, also known as mono, glandular fever, and kissing disease. The causative organism is a herpesvirus known as Epstein-Barr virus.
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 and is associated with a number of cancers, particularly lymphomaslymphoma, non-Hodgkin's,
any cancer of the lymphoid tissue (see lymphatic system) in which the Reed-Sternberg cells characteristic of Hodgkin's disease (the other category of lymphoma) are not present.
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 in immunosuppressed persons, including persons with AIDS. Epstein-Barr is a ubiquitous virus, so common that it has been difficult to determine whether it is the cause of certain diseases or whether it is simply there as an artifact. In Third World nations, most children are infected with EBV; in most industrialized nations, about 50% of the people are infected. Research has found that all of the lymphomas associated with AIDS and most lymphomas in other immunocompromised persons are connected with latent EBV infection. EBV has been found in biopsy tissue of patients with Hodgkin's diseaseHodgkin's disease,
a type of cancer of the lymphatic system. First identified in 1832 in England by Thomas Hodgkin, it is a type of malignant lymphoma. Incidence peaks in young adults and the elderly.
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, breast cancer, and some smooth muscle tumors. EBV also was formerly suspected as the cause of chronic fatigue syndromechronic fatigue syndrome
(CFS), collection of persistent, debilitating symptoms, the most notable of which is severe, lasting fatigue. In other countries it is known variously as myalgic encephalomyelitis (ME), chronic fatigue and immune dysfunction syndrome, and postviral
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 (originally named chronic EBV syndrome).

Epstein-Barr virus

An antigenically distinct member of the herpesvirus group of viruses, whose genome is DNA. EB virus is the cause of one benign disease (infectious mononucleosis), and is associated with certain types of cancer; however, the great majority of EB virus infections are clinically inapparent. The virus was detected initially by electron microscopy in a small proportion of cells in continuous lymphoblastoid cell lines derived from Burkitt's lymphoma (but particles have not been seen in cells of the tumor itself). The virus also has been detected in cell lines derived from nasopharyngeal carcinomas, a type of cancer found with high frequency in persons from southern China. The virus is found in peripheral blood leukocytes from normal individuals and from patients with infectious mononucleosis. See Infectious mononucleosis, Lymphoma

If EB virus is indeed confirmed as having a role in the development of human malignancies, then one major question to be resolved is how a virus so ubiquitous can be involved in so wide a variety of responses. However, it should be recalled that many virus infections (for example, polio virus, hepatitis viruses, certain of the arboviral encephalitides) have a wide spectrum of outcomes, ranging from inapparent infection to severe syndromes. See Animal virus

Epstein-Barr virus

[¦ep·stīn ¦bär ‚vī·rəs]
(virology)
Herpeslike virus particles first identified in cultures of cells from Burkett's malignant lymphoma.
References in periodicals archive ?
Three major possibilities are apparent to explain the greater part of the risk of lupus beyond Epstein-Barr virus association.
Plasma Epstein-Barr virus DNA and residual disease after radiotherapy for undifferentiated nasopharyngeal carcinoma.
Elevated antibody levels to Epstein-Barr virus antigens in patients with hairy cell leukemia compared to controls in relation to exposure to pesticides, organic solvents, animals, and exhausts.
Large proportion of Epstein-Barr virus associated small non-cleaved cell lymphomas among children with non Hodgkin's lymphoma at a single institution in Moscow, Russia.
Improved accuracy of detection of nasopharyngeal carcinoma by combined application of circulating Epstein-Barr virus DNA and anti-Epstein-Barr viral capsid antigen IgA antibody.
Epiphany Biosciences is a privately-held company developing therapeutic products and diagnostic technologies that treat or help prevent the spread of pathogenic viruses, including varicella virus (VZV), Epstein-Barr Virus (EBV) and hepatitis C virus (HCV).
Nasopharyngeal carcinoma: the Epstein-Barr virus association.
Cholestatic hepatitis induced by Epstein-Barr Virus infection in an adult.
Persistent Epstein-Barr virus infection: unrestricted latent and lytic viral gene expression in healthy immunosuppressed transplant recipients.
Another example is non-Hodgkin's lymphoma, which is associated with Epstein-Barr virus (the virus that causes mononucleosis or the "kissing disease").
She has been suffering from the Epstein-Barr virus which is linked to glandular fever in teenagers.
Epstein-Barr virus (EBV) plays a role in both posttransplant lymphoproliferative disorders and Hodgkin lymphoma.

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