Ergosterol


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ergosterol

[ər′gäs·tə‚rȯl]
(biochemistry)
C28H44O A crystalline, water-insoluble, unsaturated sterol found in ergot, yeast, and other fungi, and which may be converted to vitamin D2 on irradiation with ultraviolet light or activation with electrons. Also known as ergosterin.

Ergosterol

 

(also provitamin D2), C28H44O, a natural compound of the sterol group with the structural formula

Ergosterol is formed in yeast, molds, and other fungi. The crystals have a melting point of 165°C. Insoluble in water, they are soluble in organic solvents. Ergosterol is optically active, with a specific rotation of [α]D = –129°. The compound is highly reactive because of conjugate double bonds in the B ring of the system. Like cholesterol, it can form molecular complexes and inclusion complexes in cells. When irradiated with ultraviolet light, the B ring breaks, and ergosterol forms precalciferol, which is easily isomerized by heating to yield vitamin D2 (ergocalciferol).

In the pharmaceutical industry, ergosterol is used in the preparation of vitamin D2 and the hormone progesterone. Ergosterol is extracted from the alkaline hydrolyzates of baker’s yeast or the mycelial by-products from the manufacture of antibiotics.

References in periodicals archive ?
Assessment on Ganoderma Colonization based on Ergosterol Content:
Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene.
Antifungal sitokrom P-450 sistemini inhibe ederek ergosterol biyosentezini durdurur (14).
itraconazole and keto- conazole, which also targets ergosterol, but it does so by inhibiting an ergosterol precursor, i.
microbial biomass, respiration, and ergosterol concentrations, as very effective indicators for assessing long-term soil and crop management effects on soil quality.
5) Amphotericin is a polyene macrolide that binds preferentially to ergosterol in the fungal cell membrane; it also binds human cholesterol.
carbonifera tissues contained only ergosterol and ergosterol metabolites.
A reduction in this enzyme causes a decrease in fungal ergosterol synthesis, which is vital for the formation of fungal cell walls.
Analytical standards were used for the target sterol compounds coprostanol (5[beta]-choles-tan-3[beta]-ol), cholesterol, dihydrocholesterol, stigmasterol, sitosterol, stigmastanol, and ergosterol (Sigma, St.
On the stimulation of new bone formation with parathyroid extract and irradiated ergosterol.
Collecting air through a filter for 72 hours in a house, followed by ergosterol analysis provides an accurate estimate of the extent of mold damage in residential housing.
Vitamin D2 or ergocalciferol is a synthetic form derived from ultraviolet irradiation of ergosterol (a plant sterol); and is the pharmaceutical form.