Ergosterol


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ergosterol

[ər′gäs·tə‚rȯl]
(biochemistry)
C28H44O A crystalline, water-insoluble, unsaturated sterol found in ergot, yeast, and other fungi, and which may be converted to vitamin D2 on irradiation with ultraviolet light or activation with electrons. Also known as ergosterin.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Ergosterol

 

(also provitamin D2), C28H44O, a natural compound of the sterol group with the structural formula

Ergosterol is formed in yeast, molds, and other fungi. The crystals have a melting point of 165°C. Insoluble in water, they are soluble in organic solvents. Ergosterol is optically active, with a specific rotation of [α]D = –129°. The compound is highly reactive because of conjugate double bonds in the B ring of the system. Like cholesterol, it can form molecular complexes and inclusion complexes in cells. When irradiated with ultraviolet light, the B ring breaks, and ergosterol forms precalciferol, which is easily isomerized by heating to yield vitamin D2 (ergocalciferol).

In the pharmaceutical industry, ergosterol is used in the preparation of vitamin D2 and the hormone progesterone. Ergosterol is extracted from the alkaline hydrolyzates of baker’s yeast or the mycelial by-products from the manufacture of antibiotics.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
esculenta (c,**) 21.05 0.95 6.75 3.45 43.65 0.10 Vitamin Sitosterol ([micro]g/g) ([micro]g/g) Mushrooms Retinolast Ergosterol Stigmasterol [beta]- sitosterol P.
Fungicidal activity of thymol and carvacrol by disrupting ergosterol biosynthesis and membrane integrity against Candida.
La sinergia generada por la combinacion de caspofungina con farnesol esta posiblemente explicada por los efectos deletereos en la pared celular causados por la caspofungina y la alteracion de la biosintesis de ergosterol producida por el farnesol (32).
Ergosterol is responsible for integrity of the fungal cell membrane based on its bioregulatory activity on membrane fluidity and asymmetry [19].
Despite differences in degradative ability, ergosterol levels, a proxy for fungal biomass, did not differ at equivalent timepoints between the fungi and indicated ample colonization but minimal substrate degradation for S.
These fungicides probably acted as a sterol inhibitor impeding the ergosterol (fatty acid) synthesis, which is an important component of the fungal cell wall [12].
Caption: Figure 6: (a) HPTLC fingerprint profile of ergosterol (tracks 1-6) in fruit (track 7); leaf (track 8); stem (track 9); and root (track 10) of S.
Ergosterol, also called provitamin D2, is found in fungi such as Saccharomyces and other yeasts, mushrooms, and Claviceps purpurea, which causes the fungal disease ergot, for which ergosterol is named.