was determined using an Agilent model 5973 quadrupole mass spectrometer (Agilent Technologies, Inc.
Testing the association between residential fungus and health using ergosterol
measures and cough recordings.
Terbinafine inhibits ergosterol
biosynthesis through inhibition of the enzyme squalene oxidase (rather than p450 and lanosterol-converting enzymes).
The in-vitro anti-leishmanial activity of inhibitors of ergosterol
The antifungal effect of azoles is due to inhibition of sterol 14[alpha]-demethylase in fungi and yeast, thereby blocking the biosynthesis of ergosterol
(Espinel-Ingroff 1997; Georgopapadakou 1998; Joseph-Horne and Hollomon 1997).
peroxide (EP), 5[alpha], 8[alpha]-epidioxy-22E-ergosta-6, 22-dien-3[beta]-ol is a major bioactive compound isolated from the insect-body portions of Cordyceps cicadae Shing (C.
The antifungal drugs currently available for the treatment of invasive mycoses can be divided into four different classes on the basis of their mechanisms of action: (1) Alteration of membrane function (amphotericin B); (2) inhibition of DNA or RNA synthesis (flucytosine); (3) inhibition of ergosterol
biosynthesis (azoles [fluconazole, itraconazole, and the newer agents voriconazole, posaconazole, and ravuconazole]); and (4) inhibition of glucan synthesis (echinocandins [caspofungin, micafungin, and anidulafungin]).
Ravuconazole demonstrates antifungal activity by inhibiting ergosterol
biosynthesis, a membrane component of fungal cells.
Xuezhikang contains the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor lovastatin, flavonoids, ergosterol
amino acids, unsaturated fatty acids, trace elements, and other effective components.
Going into the contents of the material, the scientists did a chemical analysis to find ergosterol
, an organic molecule that could be left behind from baking, the scientists wrote, although it could also be an indicator of brewing or agriculture.
AMB, which acts by binding to ergosterol
in the cellular membrane and increasing cell permeability, is an antifungal agent with a considerably broad spectrum.
Its fungistatic action is attributed to its inhibitory action on 14[alpha]-demethylase, which converts lanosterol to ergosterol
and is required in fungal cell wall synthesis.