ergotamine

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ergotamine

[ər′gäd·ə‚mēn]
(organic chemistry)
C33H35N5O5 An alkaloid found in the fungal parasite ergot; causes smooth muscles in peripheral blood vessels to constrict, limiting blood flow; used to treat migraine headaches.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
There are currently five approved ergotamine-containing drugs: Migergot suppositories (marketed by G & W Laboratories Inc.), ergotamine tartrate and caffeine tablets (marketed by West-Ward Pharmaceutical Corporation and Mikart), Cafergot tablets (marketed by Sandoz), and Ergo-mar sublingual tablets (marketed by Rosedale Therapeutics).
NSAIDs, especially naproxen sodium, are considered an effective first choice of medication for menstrual migraine and may be administered both abortively and prophylactically for 1-2 days before the onset of migraines.[24,44] A double-blind study that compared the efficacy as well as safety of naproxen sodium and ergotamine tartrate in a sample of 79 participants with classical or common migraine found that naproxen sodium was as safe as ergotamine tartrate and somewhat more effective in acute migraine attacks.[63] Adverse effects of NSAIDs consist of gastrointestinal irritation and chronic renal dysfunction.
Lysergol, lysergic acid, ergonovine, ergonovine maleate, ergovaline, ergotamine tartrate, ergocryptine, and 2-bromo-ergocryptine were tested for cross reaction in a competitive ELISA assay.
Ergotamine -- Ergotamine tartrate has been in use since 1928 (similar formulas are Cafergot, Ergomar, Ergostat Gynergen).